Regulation of nutrient transport across the placenta.
Regulation of nutrient transport across the placenta.
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DOI：
10.1155/2012/179827
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发表时间：
2012
影响因子：
3.2
通讯作者：
Powell TL
中科院分区：
文献类型：
--
作者：
Lager S;Powell TL
胎儿生长异常，包括生长受限和过度生长，与围产期并发症有关，并增加日后患代谢和心血管疾病的风险。胎儿的生长取决于营养物质的可用性，而营养物质的可用性又与胎盘运输这些营养物质的能力有关。据报道，生长受限胎儿的胎盘中一系列营养转运蛋白的活性降低，而至少一些研究表明，胎盘营养转运在胎儿过度生长中上调。这些发现表明胎盘营养物质转运的变化可能直接导致胎儿发育异常。因此，有关胎盘营养转运蛋白调节机制的详细信息将有助于我们更好地了解妊娠并发症的重要性，并可能为设计新的干预策略提供基础。在本文中，我们将集中在最近的研究，调节胎盘转运的氨基酸，脂肪酸和葡萄糖的调节机制。
Abnormal fetal growth, both growth restriction and overgrowth, is associated with perinatal complications and an increased risk of metabolic and cardiovascular disease later in life. Fetal growth is dependent on nutrient availability, which in turn is related to the capacity of the placenta to transport these nutrients. The activity of a range of nutrient transporters has been reported to be decreased in placentas of growth restricted fetuses, whereas at least some studies indicate that placental nutrient transport is upregulated in fetal overgrowth. These findings suggest that changes in placental nutrient transport may directly contribute to the development of abnormal fetal growth. Detailed information on the mechanisms by which placental nutrient transporters are regulated will therefore help us to better understand how important pregnancy complications develop and may provide a foundation for designing novel intervention strategies. In this paper we will focus on recent studies of regulatory mechanisms that modulate placental transport of amino acids, fatty acids, and glucose.