The biocompatibility of biodegradable glycine containing polyphosphazenes: A comparative study in bone
The biocompatibility of biodegradable glycine containing polyphosphazenes: A comparative study in bone
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DOI：
10.1007/s10904-006-9096-x
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发表时间：
2006-12-01
影响因子：
4
通讯作者：
Laurencin, Cato T.
中科院分区：
文献类型：
--
作者：
El-Amin, Saadiq F.;Kwon, Michael S.;Laurencin, Cato T.
聚磷腈作为组织工程和骨科重建的生物材料已经引起了相当大的关注。在本文中，我们通过研究聚磷腈在兔股骨远端干骺端缺损模型中的骨修复能力来检查聚磷腈的体内生物相容性和降解。将由聚[（50%对甲基苯氧基）-（50%乙基甘氨酸）磷腈]（PPHOS-50）和聚[双（乙基甘氨酸）磷腈]（PPHOS-100）构建的基质作为组织再生的构建物手术植入兔股骨远端干骺端缺损中。聚（丙交酯-共-乙交酯）（PLAGA）植入物，这是临床上最广泛使用的可生物降解的聚合物，和没有聚合物的缺损在本实验中用作对照。组织学研究表明，PPHOS-50和PPHOS-100似乎支持骨生长，与对照PLAGA相当。到12周时，植入聚磷腈的股骨显示出骨长入和轻度纤维反应的证据。发现PPHOS-50植入物的局部组织反应比PPHOS-100更有利，与PLAGA相似。可生物降解的聚磷腈是一类新型的聚合物，已被观察到在体内促进骨生长。
Polyphosphazenes have gained considerable attention as biomaterials for use in tissue engineering and orthopaedic reconstruction. In this paper we examined the polyphosphazenes' in vivo biocompatibility and degradation by studying their ability to repair bone in a rabbit metaphyseal distal femur defect model. Matrices constructed from poly[(50% p-methylphenoxy)-(50%ethyl glycinato) phosphazene] (PPHOS-50) and poly[bis(ethyl glycinato) phosphazene] (PPHOS-100), were surgically implanted into a metaphyseal rabbit defect of the distal femur as constructs for tissue regeneration. Poly(lactide-co-glycolide) (PLAGA) implants, which are the biodegradable polymers most widely used clinically, and defects without polymers were used as controls in this experiment. Histological studies demonstrated that both PPHOS-50 and PPHOS-100 appeared to support bone growth comparable to the control PLAGA. By 12 weeks, femurs with polyphosphazene implants showed evidence of bone in-growth and a mild fibrous response. The PPHOS-50 implants were found to have a local tissue response that was more favorable than PPHOS-100 and similar to PLAGA. Biodegradable polyphosphazenes are a novel class of polymers which have been observed to facilitate bone growth in vivo.