Milk lipid secretion: recent biomolecular aspects.
Milk lipid secretion: recent biomolecular aspects.
复制标题
DOI：
10.1515/bmc-2012-0025
复制
发表时间：
2012-12-01
影响因子：
--
通讯作者：
McManaman JL
中科院分区：
文献类型：
--
作者：
McManaman JL
大多数物种的新生儿在出生后的生长发育过程中依赖于乳脂来获取卡路里、脂溶性维生素和生物活性脂质成分。为了满足新生儿的营养和发育需要，乳腺已经进化出了在哺乳期间合成和分泌大量脂质的有效机制。尽管人们已经了解了乳脂合成的生化步骤，但直到最近，通过小鼠遗传学、基因表达分析、蛋白质结构特性和脂质代谢细胞生物学的进展，人们才开始详细了解这些步骤的基因特征以及乳脂产生和分泌的分子生理学。这篇综述讨论了在生理功能的背景下，关于牛奶脂合成和分泌的分子、细胞和结构决定因素的新数据。
Neonates of most species depend on milk lipids for calories, fat-soluble vitamins, and bioactive lipid components for growth and development during the postnatal period. To meet neonatal nutrition and development needs, the mammary gland has evolved efficient mechanisms for synthesizing and secreting large quantities of lipid during lactation. Although the biochemical steps involved in milk lipid synthesis are understood, the identities of the genes mediating these steps and the molecular physiology of milk lipid production and secretion have only recently begun to be understood in detail through advances in mouse genetics, gene expression analysis, protein structural properties, and the cell biology of lipid metabolism. This review discusses emerging data about the molecular, cellular, and structural determinants of milk lipid synthesis and secretion within the context of physiological functions.