Epicardial fat from echocardiography: A new method for visceral adipose tissue prediction
Epicardial fat from echocardiography: A new method for visceral adipose tissue prediction
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DOI：
10.1038/oby.2003.45
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发表时间：
2003-02-01
期刊：
影响因子：
--
通讯作者：
Leonetti, F
中科院分区：
文献类型：
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作者：
Iacobellis, G;Assael, F;Leonetti, F
目的：验证经胸超声心动图作为预测内脏脂肪组织（VAT）的一种简便、可靠的成像方法。VAT被认为是心血管和代谢风险高的重要指标。几种方法适用于估计增值税，结果不同。研究方法和程序：我们选择了60名健康受试者，其中女性29名，男性31名，年龄49.5±16.2岁，身体质量指数范围广泛。每个受试者都接受了经胸超声心动图和磁共振成像（MRI）来测量右心室的心外膜脂肪厚度。心外膜脂肪组织厚度测量从相同的超声心动图和MRI视图和点获得。MRI还用于测量L4至L5水平的VAT横截面积。还测量了人体测量指数。结果：以内脏脂肪堆积为主的受试者心外膜脂肪组织厚度高于以外周脂肪分布为主的受试者：男性和女性分别为9.97 +/- 2.88比4.34 +/- 1.98 （P = 0.005）和7.19 +/- 2.74比3.43 +/- 1.64 （P = 0.004）。简单线性回归分析显示，心外膜脂肪组织与腰围（r = 0.895, p = 0.01）和MRI腹部VAT （r = 0.864, p = 0.01）具有极好的相关性。多元回归分析显示，心外膜脂肪组织厚度（r(2) = 0.442, p = 0.02）是与MRI VAT相关性最强的自变量。Bland试验证实了两种方法的良好一致性。讨论：心外膜脂肪组织与VAT的人体测量和成像测量有很强的相关性。因此，经胸超声心动图是一种简便、可靠的VAT预测方法。
Objective: To validate transthoracic echocardiography as an easy and reliable imaging method for visceral adipose tissue (VAT) prediction. VAT is recognized as an important indicator of high cardiovascular and metabolic risk. Several methods are applied to estimate VAT, with different results.Research Methods and Procedures: We selected 60 healthy subjects (29 women, 31 men, 49.5 +/- 16.2 years) with a wide range of body mass indexes. Each subject underwent transthoracic echocardiogram and magnetic resonance imaging (MRI) to measure epicardial fat thickness on the right ventricle. Measurements of epicardial adipose tissue thickness were obtained from the same echocardiographic and MRI views and points. MRI was also used to measure VAT cross-sectional areas at the level of L4 to L5. Anthropometric indexes were also measured.Results: Subjects with predominant visceral fat accumulation showed higher epicardial adipose tissue thickness than subjects with predominant peripheral fat distribution: 9.97 +/- 2.88 vs. 4.34 +/- 1.98 (P = 0.005) and 7.19 +/- 2.74 vs. 3.43 +/- 1.64 (p = 0.004) in men and women, respectively. Simple linear regression analysis showed an excellent correlation between epicardial adipose tissue and waist circumference (r = 0.895, p = 0.01) and MRI abdominal VAT (r = 0.864, p = 0.01). Multiple regression analysis showed that epicardial adipose tissue thickness (r(2) = 0.442, p = 0.02) was the strongest independent variable correlated to MRI VAT. Bland test confirmed the good agreement between the two methods.Discussion: Epicardial adipose tissue showed a strong correlation with anthropometric and imaging measurements of VAT. Hence, transthoracic echocardiography could be an easy and reliable imaging method for VAT prediction.