Family history of alcoholism influences naltrexone-induced reduction in alcohol drinking
Family history of alcoholism influences naltrexone-induced reduction in alcohol drinking
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DOI：
10.1016/j.biopsych.2006.11.018
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发表时间：
2007-09-15
影响因子：
10.6
通讯作者：
O'Malley, Stephanie S.
中科院分区：
文献类型：
--
作者：
Krishnan-Sarin, Suchitra;Krystal, John H.;O'Malley, Stephanie S.
背景资料：本研究的目的是探讨酒精中毒家族史（FH+，FH-）和纳洛酮剂量（0，50，100毫克/天）对酒精drinking.Methods：92，非治疗寻求酒精依赖的参与者接受纳洛酮每天6天的相互作用。在第6天，他们参加了一个实验室的范例，涉及暴露于启动剂量的酒精，然后由2小时的饮酒期间，他们之间的消费酒精饮料和接收money.Results的选择：饮酒期间消耗的饮料总数显着减少了100毫克剂量的纳曲酮在FH+饮酒者。在男性饮酒者（n = 70）的二次分析表明，100毫克的纳洛酮显着减少饮酒FH+参与者和增加饮酒FH - drinkers.Conclusions：这些结果表明，酒精中毒的家族史可能是一个显着的临床预测纳洛酮和FH+男性更有可能受益于纳洛酮治疗饮酒。
Background: The purpose of this study was to examine the interactive effects of family history of alcoholism (FH+, FH-) and naltrexone dose (0, 50, 100 mg/day) on alcohol drinking.Methods: Ninety-two, non-treatment-seeking alcohol-dependent participants received naltrexone daily for 6 days. On the 6th day, they participated in a laboratory paradigm involving exposure to a priming dose of alcohol followed by a 2-hour drinking period in which they made choices between consuming alcoholic drinks and receiving money.Results: Total number of drinks consumed during the drinking period was significantly decreased by the 100-mg dose of naltrexone in FH+ drinkers. Secondary analyses in male drinkers (n = 70) indicated that 100 mg of naltrexone significantly decreased drinking in FH+ participants and increased drinking in FH - drinkers.Conclusions: These results suggest that family history of alcoholism might be a significant clinical predictor of response to naltrexone and that FH+ men are more likely to benefit from naltrexone therapy for alcohol drinking.