Von Willebrand factor and ADAMTS13 activity as clinical severity markers in patients with COVID-19.
Von Willebrand factor and ADAMTS13 activity as clinical severity markers in patients with COVID-19.
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DOI：
10.1007/s11239-021-02457-9
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发表时间：
2021-08
影响因子：
4
通讯作者：
Marco P
中科院分区：
文献类型：
--
作者：
Marco A;Marco P
2019冠状病毒病（COVID-19）增加了血栓形成的风险。导致这种血栓前状态的机制尚未完全确定。主要目的是评估血管性血友病因子（VWF）抗原和血浆ADAMTS 13活性作为COVID-19中的内皮损伤标志物。我们在本机构招募的COVID-19患者中开展了一项前瞻性研究。一旦确诊COVID-19，在第一周内测量VWF抗原、ADAMTS 13活性、D-二聚体和纤维蛋白原。入组了50名COVID-19住院患者[44%在重症监护室（ICU）]和102名COVID-19门诊患者。招募了30名年龄和性别匹配的非COVID-19病房住院患者和30名非COVID-19健康个体。与COVID-19门诊患者相比，COVID-19住院患者的D-二聚体、纤维蛋白原和VWF抗原水平较高，ADAMTS 13活性较低（p < 0.05）。ICU患者D-二聚体和VWF抗原水平显著高于病房患者，ADAMTS 13活性显著低于病房患者（P < 0.05）。在COVID-19中观察到VWF抗原/ADAMTS 13比例失衡，在ICU患者中达到最高。与其他病房非COVID-19住院患者相比，在所有COVID-19患者中观察到ADAMTS 13活性显著降低。在COVID-19中，VWF抗原增加和ADAMTS 13活性降低与疾病严重程度相关，并可预测不良临床结局。ADAMTS 13活性降低可能是与COVID-19相关的标志物，而不是其他非危重疾病。
The coronavirus disease 2019 (COVID-19) increases thrombotic risk. The mechanisms that lead to this prothrombotic state are not well established. The main aim was to evaluate the von Willebrand factor (VWF) antigen and plasma ADAMTS13 activity as endothelial injury markers in COVID-19. We present a prospective study in COVID-19 patients recruited in our institution. VWF antigen, ADAMTS13 activity, D-dimer, and fibrinogen were measured during the first week once COVID-19 was diagnosed. Fifty COVID-19 inpatients [44% in the intensive care unit (ICU)] and 102 COVID-19 outpatients were enrolled. Thirty age and gender matched non-COVID-19 ward inpatients and 30 non-COVID-19 healthy individuals were recruited. The COVID-19 inpatients had higher D-dimer, fibrinogen, and VWF antigen levels and a lower ADAMTS13 activity compared with the COVID-19 outpatients (p < 0.05). ICU patients had higher D-dimer and VWF antigen levels compared with the ward patients and the lowest ADAMTS13 activity (p < 0.05). An imbalance in VWF antigen/ADAMTS13 ratio was observed in COVID-19, reaching the highest in ICU patients. In contrast to other ward non-COVID-19 inpatients, a significative reduction in ADAMTS13 activity was observed in all COVID-19 patients. There is an increase in VWF antigen and an ADAMTS13 activity reduction in COVID-19 related to disease severity and could predict poor clinical outcomes. The ADAMTS13 activity reduction could be a marker associated with COVID-19 compared to other non-critical medical conditions.
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影响因子：
168.9
作者：
Huang, Chaolin;Wang, Yeming;Cao, Bin
通讯作者：
Cao, Bin
影响因子：
4
作者：
Zhang, Yan;Cao, Wei;Zhu, Tienan
通讯作者：
Zhu, Tienan
DOI：
10.1111/jth.14849
发表时间：
2020-07
期刊：
Journal of thrombosis and haemostasis : JTH
影响因子：
--
作者：
通讯作者：
--
影响因子：
5
作者：
Lippi, Giuseppe;Plebani, Mario;Henry, Brandon Michael
通讯作者：
Henry, Brandon Michael
影响因子：
4
作者：
Pavoni, Vittorio;Gianesello, Lara;Frigieri, Francesca Covani
通讯作者：
Frigieri, Francesca Covani