Clinical characteristics and outcomes of primary adrenal diffuse large B cell lymphoma in a large contemporary cohort: a SEER-based analysis
Clinical characteristics and outcomes of primary adrenal diffuse large B cell lymphoma in a large contemporary cohort: a SEER-based analysis
复制标题
当代大型队列中原发性肾上腺弥漫性大 B 细胞淋巴瘤的临床特征和结果：基于 SEER 的分析
DOI：
10.1007/s00277-019-03740-9
复制
发表时间：
2019-09-01
影响因子：
3.5
通讯作者：
Xu, Yang
中科院分区：
文献类型：
--
作者：
Li, Shu;Wang, Zhan;Xu, Yang
原发性肾上腺淋巴瘤（PAL）是一种极为罕见的淋巴瘤，最常见的组织学类型是弥漫性大B细胞淋巴瘤（DLBCL）。原发性肾上腺大细胞淋巴瘤预后很差，但其预后决定因素很少报道。通过监测、流行病学和最终结果（SEER）项目，我们收集了1983年至2015年原发性肾上腺大细胞淋巴瘤患者的人口统计学、临床和治疗信息。Kaplan-Meier法获得总生存期（OS）和病因特异性生存期（CSS）曲线。采用Cox比例风险回归模型，结合单因素和多因素分析评估OS和CSS的预后价值。我们的队列共纳入136例患者。肾上腺大细胞淋巴瘤以男性和老年人为主，单侧肾上腺源性发生率高。患者更有可能出现晚期疾病。肾上腺型DLBCL患者全队列5年和10年的OS率分别为19.17%和3.33%，5年和10年的CSS率也有类似的结果。年龄大于70岁和双侧是与不良OS和CSS相关的独立预后因素，化疗患者的OS和CSS优于未接受治疗的患者。
Primary adrenal lymphoma (PAL) is an extremely rare lymphoma, and the most common histologic type is diffuse large B cell lymphoma (DLBCL). Primary adrenal DLBCL has a quite poor prognosis, but the prognostic determinants are rarely reported. With the Surveillance, Epidemiology, and End Results (SEER) program, we collected the demographic, clinical, therapeutic information of patients with primary adrenal DLBCL from 1983 to 2015. The Kaplan-Meier method was used to obtain overall survival (OS) and cause-specific survival (CSS) curves. The prognostic values of OS and CSS were assessed using Cox proportional hazards regression model with univariate and multivariate analyses. A total of 136 patients were included in our cohort. Adrenal DLBCL predominantly affected male and the aged, and there was a high rate of unilateral adrenal origin. The patients were more likely to present advanced stage disease. The OS rates of the entire cohort of patients with adrenal DLBCL at 5 and 10 years were respectively 19.17% and 3.33%, and the similar results were shown in 5-year and 10-year CSS rates. Age more than 70 years old and bilateral were identified as independent prognostic factors that were correlated with both adverse OS and CSS, and patients with chemotherapy had a superior OS and CSS to the patients without any treatment.