Intraurethral honey application for urethral injury:: an experimental study
Intraurethral honey application for urethral injury:: an experimental study
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DOI：
10.1007/s11255-006-9152-z
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发表时间：
2007-09-01
影响因子：
2
通讯作者：
Germiyanoglu, Cankon
中科院分区：
文献类型：
--
作者：
Ayyildiz, Ali;Akguel, K. Turgay;Germiyanoglu, Cankon
目的探讨蜂蜜对尿道损伤后尿道组织病理愈合的影响。材料与方法选用Wistar雄性大鼠。将大鼠分为4组：对照组（1组）、假手术组（2组）、蜂蜜敷1周组（3组）、蜂蜜敷3周组（4组）。尿道损伤用29g针穿刺。假手术组仅给予生理盐水经尿道灌胃，第三、四组大鼠经尿道灌胃10%蜂蜜。杀死后，在光镜下观察阴茎组织。结果1组大鼠尿道上皮及结缔组织出现异常。对照组大鼠除1只无炎症和完全愈合外，其余大鼠均出现管腔狭窄。在整个大鼠中发现充血。2组尿道上皮及结缔组织异常。一只大鼠观察到完全愈合。第3组，6只大鼠尿道上皮结构正常，无炎症和纤维化。第4组大鼠未见炎症和纤维组织堆积。结论尿道损伤后应用尿道蜂蜜可预防炎症，加速尿道愈合，提供完美的愈合。
Objectives To evaluate the effect of honey applied intraurethrally after urethral injury on histopathological healing. Materials and methods A total of Wistar male rats were used. The rats were divided into four groups: control (Group 1), sham (Group 2), 1 week honey applied group (Group 3) and 3 weeks honey applied group (Group 4). The urethral damage was caused with a 29 G needle. In sham group, only intraurethral saline solution was given, and 10% of honey was applied to rats in Groups 3 and 4 intraurethrally. After killing, penile tissues were investigated under a light microscopy. Results The irregularities of urethral epithelium and connective tissue were observed in Group 1. Also narrowing of lumen was present in control group rats except one rat in which no inflammation and total healing were observed. Hyperemia-bleeding was found in whole rats. In Group 2, there were irregularities in urethral epithelium and connective tissue. Total healing was observed in one rat. In Group 3, while regularity in urethral epithelium was present in six rats, inflammation and fibrosis was absent in rats. In Group 4, inflammation and fibrous tissue accumulation were not observed in rats. Conclusions Intraurethral honey, applied after urethral injury, prevents inflammation, accelerates urethral healing and provides perfect healing.