Phonological short-term memory in logopenic variant primary progressive aphasia and mild Alzheimer's disease.
Phonological short-term memory in logopenic variant primary progressive aphasia and mild Alzheimer's disease.
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DOI：
10.1016/j.cortex.2015.07.003
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发表时间：
2015-10
期刊：
影响因子：
--
通讯作者：
Friedman RB
中科院分区：
文献类型：
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作者：
Meyer AM;Snider SF;Campbell RE;Friedman RB
语音缺失变异原发性进行性失语症（lvPPA）患者的语音回路受损，而语音回路是短期记忆系统的一个组成部分。相反，这种类型的损伤被认为不存在于轻度典型阿尔茨海默病（AD）中。因此，人们可以预测，lvPPA患者在需要语音STM的任务上的得分明显低于匹配的AD组。在目前的研究中，将lvPPA组与年龄、教育程度和一般认知功能相匹配的轻度AD组进行比较。在一些涉及假词的任务中，将AD和lvPPA组与年龄和教育程度相匹配的健康对照组进行比较。lvPPA组在所有需要语音STM的任务上比AD组受损更严重，包括假词任务，但在需要视觉空间STM的任务上，两组之间没有显著差异。与健康对照组相比，lvPPA组在重复和阅读假词方面的表现明显较差，而AD组在这些任务上与对照组没有显着差异。这些发现与lvPPA中语音STM受损的假设一致。
It has been argued that individuals with logopenic variant primary progressive aphasia (lvPPA) have an impairment of the phonological loop, which is a component of the short-term memory (STM) system. In contrast, this type of impairment is not thought to be present in mild typical Alzheimer’s disease (AD). Thus, one would predict that people with lvPPA would score significantly lower than a matched AD group on tasks that require phonological STM. In the current study, an lvPPA group was compared with a mild AD group that was matched on age, education, and general cognitive functioning. For a subset of the tasks that involved pseudowords, the AD and lvPPA groups were compared to a healthy control group that was matched on age and education. The lvPPA group was more impaired than the AD group on all of the tasks that required phonological STM, including the pseudoword tasks, but there were no significant differences between these groups on tasks that required visuospatial STM. Compared to the healthy controls, the lvPPA group performed significantly worse on the repetition and reading of pseudowords, while the AD group did not differ significantly from the controls on these tasks. These findings are consistent with the hypothesis that phonological STM is impaired in lvPPA.