Correlation between lopinavir plasma levels and lipid abnormalities in patients taking lopinavir/ritonavir
Correlation between lopinavir plasma levels and lipid abnormalities in patients taking lopinavir/ritonavir
复制标题
DOI：
10.1089/108729103322395465
复制
发表时间：
2003-09-01
影响因子：
4.9
通讯作者：
Soriano, V
中科院分区：
文献类型：
--
作者：
De Requena, DG;Blanco, F;Soriano, V
洛匹那韦（LPV）/利托那韦（RTV）联合使用是一种有效的抗逆转录病毒药物。然而，其益处受到其对脂质代谢的固有影响的限制，导致大部分接受治疗的患者出现贫血。对126例基于LPV/RTV开始挽救治疗的HIV感染患者的空腹甘油三酯（TG）和胆固醇水平进行了评估。从基线至第3个月，TG和胆固醇均显著升高。TG升高百分比与LPV谷值水平呈正相关（r = 0.32; p = 0.003）。此外，TG升高高于中位数的患者（27%）的LPV Ctrough水平高于TG升高较低的患者（7.1 vs. 4.7 mug/ml，p = 0.004）。相比之下，未发现LPV Ctrough与胆固醇水平升高之间存在相关性。胆固醇升高与RTV Ctrough浓度呈正相关（r = 0.32; p = 0.003）。
Lopinavir (LPV)/ritonavir (RTV) used in combination, is a potent antiretroviral drug. However, its benefit is limited by its inherent effect on lipid metabolism, causing dislypemia in a large proportion of treated patients. Fasting triglyceride (TG) and cholesterol levels were assessed in 126 HIV-infected patients who initiated salvage therapy based on LPV/RTV. Both TG and cholesterol significantly increased from baseline to month 3. A positive correlation was found between the percentage increase in TG and LPV trough levels (r = 0.32; p = 0.003). Moreover, patients with TG elevations above the median (27%) showed higher LPV Ctrough levels than those with lower TG elevations (7.1 vs. 4.7 mug/ml, p = 0.004). In contrast, no correlation was found between LPV Ctrough and increases in cholesterol levels. Cholesterol elevations were positively correlated with RTV Ctrough concentrations (r = 0.32; p = 0.003).