NADPH oxidase.
NADPH oxidase.
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DOI：
10.1016/s1357-2725(96)00084-2
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
K. P. Shatwell;A. Segal
中科院分区：
文献类型：
--
作者：
K. P. Shatwell;A. Segal
超氧化物在吞噬细胞杀死微生物方面起着重要作用。它是由NADPH氧化酶系统产生的，这是一个膜结合的电子传输复合体，将电子从细胞质中的NADPH通过吞噬液泡的壁泵送到分子氧。超氧物缺乏会导致遗传性慢性肉芽肿性疾病(CGD)，患者极易受到感染。近年来，CGD中的许多潜在的遗传缺陷已经被发现，并为NADPH氧化酶复合体的结构和机制提供了重要的见解。
Superoxide is instrumental in the killing of microorganisms by phagocytic cells. It is generated by the NADPH oxidase system, a membrane-bound electron transport complex which pumps electrons from NADPH in the cytoplasm across the wall of the phagocytic vacuole to molecular oxygen. Superoxide deficiency results in the genetically inherited condition Chronic Granulomatous Disease (CGD), in which the patient is abnormally susceptible to infection. In recent years many of the underlying genetic defects in CGD have been identified and are providing important insights into the structure and mechanism of the NADPH oxidase complex.