Primordial Odontogenic Tumor: A case report with histopathological analyses.
Primordial Odontogenic Tumor: A case report with histopathological analyses.
复制标题
原始牙源性肿瘤：带有组织病理学分析的病例报告。
DOI：
10.1111/pin.12601
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发表时间：
2017
影响因子：
2.2
通讯作者：
Takeda Y.
中科院分区：
文献类型：
--
作者：
Mikami T;Ohashi Y;Bologna-Molina R;Mosqueda-Taylor A;Fujiwara N;TsunodaN;Yamada H;Takeda Y.
原发性牙源性肿瘤（POT）是一种良性混合上皮和间叶牙源性肿瘤，于2017年纳入世界卫生组织（WHO）头颈部肿瘤分类。据作者证实，迄今为止只有8例这种肿瘤的报道。本文报告了一例发生在5岁患者右下颌骨的POT病例。全景X线片显示边界清晰的均匀透亮线将未萌出的第二乳磨牙移位至下颌骨深部。组织学上，肿瘤由富含细胞的间充质组织和粘液样区域组成，外层被柱状上皮和非角化立方上皮包围。组织病理学诊断为POT。细胞角蛋白（CK）14、18、19、波形蛋白（vimentin）和CD 34的表达模式表明，在帽状期至钟状晚期，POT的分化程度与正常初级牙胚组织的分化程度大致相当。
Primordial odontogenic tumor (POT) is a benign mixed epithelial and mesenchymal odontogenic tumor included into the current World Health Organization (WHO) classification of Head and Neck tumours in 2017. As far as the authors have confirmed, only eight cases of this tumor have been reported so far. This paper reports a case of POT that occurred in the right mandible of a 5‐year‐old patient. Panoramic radiograph showed a well‐defined homogeneous radiolucency displacing the unerupted second deciduous molar to the deep part of the mandible. Histopathologically, the tumor was composed of cell‐rich mesenchymal tissue with myxoid areas, surrounded by columnar epithelium and non‐keratinized cuboidal epithelium in the outer layers. The histopathological diagnosis was POT. The expression patterns of cytokeratins (CK) 14, 18, 19, vimentin and CD34 suggested that the grade of differentiation of the POT was approximately equivalent to that of normal primary tooth germ tissues in cap stage to late bell stage.