Association study between plasma GDNF and cognitive function in late-onset depression
Association study between plasma GDNF and cognitive function in late-onset depression
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迟发性抑郁症血浆GDNF与认知功能的相关性研究
DOI：
10.1016/j.jad.2011.03.043
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发表时间：
2011-08-01
影响因子：
6.6
通讯作者：
Zhang, Zhijun
中科院分区：
文献类型：
--
作者：
Wang, Xiaoquan;Hou, Zhenghua;Zhang, Zhijun
目的：越来越多的证据表明，神经营养生长因子系统可能参与重性抑郁症（MDD）的病理生理。胶质细胞源性神经营养因子（glial cell line-derived neurotrophic lac：tor，GDNF）是转化生长因子β（transforming growth factor β，TGF β）家族中的一种神经营养因子，在海马细胞的发育和功能中发挥重要作用。本研究旨在探讨晚发性抑郁症（LOD）患者血浆GDNF水平是否异常，以及是否与LOD的认知功能损害有关。方法：采用ELISA法测定27例LOD患者抗抑郁治疗前和28例正常对照者血浆GDNF水平。结果：除TMT-B外，LOD组神经心理测验成绩均显著低于对照组。LOD患者血浆GDNF水平显著高于对照组（P
Objective: Improving evidence suggest that neurotrophic growth factor systems might be involved in the pathophysiology of major depressive disorder (MDD). The glial cell line-derived neurotrophic lac:tor (GDNF) is a neurotrophic factor from the transforming growth factor-beta-family, which plays a role in the development and function of hippocampal cells. This study was aimed to test whether GDNF in plasma was abnormal in late-onset depression (LOD), and whether it was associated with the cognitive impairment of LOD.Methods: The plasma GDNF levels in LOD patients (n = 27) before antidepressant treatment and normal control subjects (n = 28) were measured with the ELISA method. All subjects were assessed by neuropsychological tests and Hamilton Depression Rating Scale (HDRS).Results: The performance of neuropsychological tests of the LOD group except TMT-B was significantly poorer than those of the control group. The plasma GDNF levels in LOD patients were significantly increased compared to control subjects (P