Serum miR-17 levels are downregulated in obese, African American women with elevated HbA1c
Serum miR-17 levels are downregulated in obese, African American women with elevated HbA1c
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DOI：
10.1007/s40200-019-00404-3
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发表时间：
2019-05
影响因子：
2.8
通讯作者：
Ariel Williams;Dara Mc Dougal;Willysha S. Jenkins;Natasha Greene;ClarLynda R. Williams-DeVane;K. Kimbro
中科院分区：
文献类型：
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作者：
Ariel Williams;Dara Mc Dougal;Willysha S. Jenkins;Natasha Greene;ClarLynda R. Williams-DeVane;K. Kimbro
目的2型糖尿病是一种以高血糖等多种病症为特征的异质性疾病。据估计，全球有超过3.5亿人患有2型糖尿病，这一数字预计还会上升。根据美国疾病控制与预防中心的数据，非洲裔美国人的糖尿病发病率比欧洲裔美国人高出40%。表观遗传调控机制，如microRNAs(MiRNAs)，最近被认为是代谢综合征、肥胖和2型糖尿病的一个巨大的调控机器。本研究旨在探讨肥胖、糖化血红蛋白升高的非裔美国女性血清miR-17(miR-17)水平的变化。结果HbA1c增高者与HbA1c正常者相比，其血清miR-17水平下调。在糖化血红蛋白正常的受试者中，miR-17与血钙也呈正相关。结论提示血清miR-17参与了血糖和钙稳态的调节，可能参与了2型糖尿病的发生发展。
PurposeType 2 diabetes is heterogeneous disease characterized by several conditions including hyperglycemia. It is estimated that over 350 million people worldwide are suffering from type 2 diabetes and this number is expected to rise. According to the CDC, African Americans were observed to have a 40% higher incidence of diabetes compared to European Americans. Epigenetic modulating mechanisms such as microRNAs (miRNAs), have recently been established as a massive regulatory machine in metabolic syndrome, obesity and type 2 diabetes. In the present study, we aimed to investigate the serum levels of circulating miRNA 17 (miR-17) of obese, African American women with elevated HbA1c.MethodsWe investigated miR-17 serum levels using qPCR. Then we used Pairwise Pearson Correlation Test to determine the relationship between clinical metabolic parameters and miR-17 serum levels.ResultsThe results indicated that participants with elevated HbA1cexhibited a down regulation of serum miR-17 levels compared to participants with normal HbA1c. MiR-17 was also correlated with serum calcium in participants with normal HbA1c.ConclusionsThe results suggest that serum miR-17 is involved in the regulation of glucose and calcium homeostasis, which may contribute to the development of type 2 diabetes.