INHIBITORY ACTIVITY OF PROTECTED EDIBLE PLANTS ON OXIDATIVE STRESS INDUCED BY ORAL 1,4-DIOXANE.
INHIBITORY ACTIVITY OF PROTECTED EDIBLE PLANTS ON OXIDATIVE STRESS INDUCED BY ORAL 1,4-DIOXANE.
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受保护的食用植物对口服 1,4-二恶烷引起的氧化应激的抑制活性。
DOI：
10.12816/0026159
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
H. I. Mahmoud
中科院分区：
文献类型：
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作者：
Said Mnaa;E. Shaker;H. I. Mahmoud
具有两个氧原子的1，4-二氧六环（DX）使其具有亲水性，并无限溶于水。作为一种合成有机化合物，它在整个工业中广泛用作溶剂。二恶英会导致许多人类疾病，例如肝损伤和肾衰竭。研究表明，它对动物致癌，对人类也是一种潜在的致癌物质。除正常对照组外，体重120 g的大鼠每日饮用1，4-二氧六环（100 mg/kg体重）。对实验动物进行42天的体重、血清碱性磷酸酶、血清肌酐、丙二醛和过氧化氢酶活性随访;此外还观察肝、肾、脑和卵巢切片的组织学模式。已使用口服注射N-乙酰半胱氨酸（100 mg/kg b.w.）提供保护治疗，和新鲜200 mg/kg b.wt.在不同组中，Nabk、谷壳和西卡莫尔各自的饮食餐中。体重和CAT活性分别下降了25.8%和68.7%。MDA、ALP和肌酐值分别增加76%、48.9%和67.3%。NAC显示改善，尤其是MDA过氧化标记物和肌酐（肾脏疾病）。另一方面，nabk提高了CAT活性和ALP肝致突变标记物的外壳。DX中毒后，肝、肾、脑组织水肿，枯否细胞活化，肾小球萎缩，神经元坏死。显然，nabk在肝毒性方面显示出高度改善，肝毒性是研究中发现的对DX最敏感的器官。
1,4-Dioxane (DX) with two oxygen atoms make it hydrophilic and infinitely soluble in water. As a synthetic organic compound, it used widely throughout industry as a solvent. Dioxane causes numerous human ailments such as liver damage and kidney failure. It has been shown in research to be carcinogenic to animals, and is a potential carcinogen to humans. Daily administration for 1,4-dioxane (100 mg/kg body weight) in drinking water for rats weighing 120 g, except for normal control group. Experimental animal for 42 days was followed through body weight, serum alkaline phosphatase, serum creatinine, malondialdehyde, and catalase enzyme activity; beside histological patterns for liver, kidney, brain and ovary sections. Protection treatment has been offered using oral injection N-acetyl cysteine (100 mg/kg b.wt.), and fresh 200 mg/kg b.wt. in diet meal for each of nabk, husk, and sycamore in separated groups. Body weight and CAT activity have decreased by 25.8, and 68.7%, respectively. While increase has found in MDA, ALP and creatinine values by 76, 48.9, and 67.3%, respectively. NAC showed improvement especially for MDA peroxidation marker and creatinine for kidney disorder. On the other hand, nabk improved CAT activity and husk for ALP liver mutagenicity marker. Intoxicated DX showed edema, kupffer cell activation, atrophy of glomerular tuft, and necrosis of neurons in liver, kidney and brain sections. Obviously nabk showed highly improvement in liver toxicity which is the most sensitive organ to DX as found in research.