CYCLIC SEASONAL-VARIATION IN PLASMA-LIPID AND LIPOPROTEIN LEVELS - THE LIPID RESEARCH CLINICS CORONARY PRIMARY PREVENTION TRIAL PLACEBO GROUP
CYCLIC SEASONAL-VARIATION IN PLASMA-LIPID AND LIPOPROTEIN LEVELS - THE LIPID RESEARCH CLINICS CORONARY PRIMARY PREVENTION TRIAL PLACEBO GROUP
复制标题
DOI：
10.1016/0895-4356(88)90120-5
复制
发表时间：
1988-01-01
影响因子：
7.2
通讯作者：
EKELUND, LG
中科院分区：
文献类型：
--
作者：
GORDON, DJ;HYDE, J;EKELUND, LG
研究人员对 1446 名 35-59 岁高胆固醇血症男性的季节性血浆脂质和脂蛋白周期进行了研究，作为脂质研究诊所 (LRC) 冠状动脉一级预防试验 (CPPT) 的安慰剂组，随访了 7 年。为每个研究参与者计算单独的周期时间序列；平均参数估计是通过向量代数获得的。血浆总胆固醇 (TOT-C)、低密度脂蛋白 (LDL-C) 和高密度脂蛋白 (HDL-C) 水平具有高度显着性 (p < 0.001) 同步正弦季节性周期，在冬季第一个月达到峰值。它们的平均季节变化（最低点到最高点）分别为 7.4、6.4 和 0.8 mg/dl。血浆甘油三酯 (TG) 水平也存在不规则但具有统计学意义的季节性模式，在秋季达到峰值。这些季节性影响在亚组和地理区域之间的变化及其与季节性体重和饮食模式的相关性对于其潜在的病因机制几乎没有提供任何线索。
Seasonal plasma lipid and lipoprotein cycles were studied in 1446 hypercholesterolemic 35-59 year-old men followed for 7 years as the placebo group of the lipid Research Clinics (LRC) Coronary Primary Prevention Trial (CPPT). Separate periodic time series were calculated for each study participant; mean parameter estimates were obtained by vector algebra. Highly significant (p < 0.001) synchronous sinusoidal seasonal cycles, peaking in the first month of winter, were demonstrated for plasma levels of total (TOT-C), low-density lipoprotein (LDL-C), and high-density lipoprotein (HDL-C) cholesterol. Their mean seasonal changes (nadir to zenith) were 7.4, 6.4, and 0.8 mg/dl, respectively. An irregular but statistically significant seasonal pattern was also observed for plasma triglyceride (TG) levels, with peak levels in the autumn. The variation of these seasonal effects among subgroups and geographic locales and their correlation with seasonal weight and dietary patterns yielded few clues as to their underlying etiologic mechanisms.