Parental diet and risk of retinoblastoma resulting from new germline RB1 mutation
Parental diet and risk of retinoblastoma resulting from new germline RB1 mutation
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DOI：
10.1002/em.21705
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发表时间：
2012-07-01
影响因子：
2.8
通讯作者：
Ganguly, Arupa
中科院分区：
文献类型：
--
作者：
Bunin, Greta R.;Tseng, Marilyn;Ganguly, Arupa
我们进行了一项散发性双侧视网膜母细胞瘤的病例对照研究，该肿瘤是由一个新的生殖系RB1突变引起的，以调查父母在孩子受孕前饮食的作用。来自9个北美机构和269个对照组的206个病例的父母参加了调查；其中184个病例和223个对照组的父亲和204个病例和260个对照组的母亲通过电话回答了关于孩子怀孕前一年饮食的食物频率问卷。2例提供了用于RB1突变检测的DNA。我们通过检查19种食物来评估父母的饮食。父亲摄入奶制品和水果会降低患病风险，而腌制肉类和糖果会增加患病风险。在任何食物组中，母亲的摄入量与疾病无关。考虑到调整了与疾病、能量摄入量和人口统计特征显著相关的其他食物组的分析，以及更充分调整的模型，与父亲的乳制品和腌肉摄入量的相关性最强。在完全调整的配对分析中，乳制品和腌肉的每日供应的优势比分别为0.70和5.05(95%可信区间为0.491.00，P=0.047)。与父亲的饮食而不是母亲的饮食有关的模式与85%的新生殖系RB1突变发生在父亲的等位基因上的事实一致。由于几乎没有关于饮食在由新的生殖细胞突变引起的任何情况下所起作用的人类数据，因此需要更多的研究来重复或驳斥我们的发现。环境。摩尔。诱变剂。2012年。(C)2012年威利期刊公司。
We conducted a casecontrol study of sporadic bilateral retinoblastoma, which results from a new germline RB1 mutation, to investigate the role of parents' diet before their child's conception. Parents of 206 cases from nine North American institutions and 269 controls participated; of these, fathers of 184 cases and 223 controls and mothers of 204 cases and 260 controls answered a food frequency questionnaire administered by phone about their diet in the year before the child's conception. Cases provided DNA for RB1 mutation testing. We assessed parents' diet by examining 19 food groups. Father's intake of dairy products and fruit was associated with decreased risk and cured meats and sweets with increased risk. Mother's intake was not associated with disease for any food group. Considering analyses adjusted for the other food groups significantly associated with disease, energy intake, and demographic characteristics as well as more fully adjusted models, the associations with father's dairy products and cured meat intake were the most robust. In the fully adjusted, matched analysis, the odds ratios per daily serving were 0.70 (95% confidence interval (CI) 0.491.00, P = 0.047) for dairy products and 5.05 (CI 1.4617.51, P = 0.01) for cured meat. The pattern of associations with paternal but not maternal diet is consistent with the fact that 85% of new germline RB1 mutations occur on the father's allele. As few human data exist on the role of diet in any condition resulting from new germ-cell mutation, additional studies will be needed to replicate or refute our findings. Environ. Mol. Mutagen. 2012. (c) 2012 Wiley Periodicals, Inc.