Phosphorescent heavy-metal complexes for bioimaging.
Phosphorescent heavy-metal complexes for bioimaging.
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DOI：
10.1039/c0cs00114g
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发表时间：
2011-04
影响因子：
46.2
通讯作者：
Qiang Zhao;Chunhui Huang;Fuyou Li
中科院分区：
文献类型：
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作者：
Qiang Zhao;Chunhui Huang;Fuyou Li
具有d（6）、d（8）和d（10）电子构型的磷光重金属配合物在生物成像中的应用是一个新的研究领域，近年来引起了人们的广泛兴趣。在这篇评论中，我们系统地评估了磷光重金属配合物作为生物成像探针的优势，包括它们的物理性质，细胞毒性和细胞摄取机制。本文综述了磷光重金属配合物在细胞不同区室染色、细胞内功能物种监测、靶向生物成像、双光子生物成像、小动物生物成像、多模式生物成像和时间分辨生物成像等方面的研究进展。此外，还讨论了该领域未来可能的发展方向（参考文献133篇）。
The application of phosphorescent heavy-metal complexes with d(6), d(8) and d(10) electron configurations for bioimaging is a new and promising research field and has been attracting increasing interest. In this critical review, we systematically evaluate the advantages of phosphorescent heavy-metal complexes as bioimaging probes, including their photophysical properties, cytotoxicity and cellular uptake mechanisms. The progress of research into the use of phosphorescent heavy-metal complexes for staining different compartments of cells, monitoring intracellular functional species, providing targeted bioimaging, two-photon bioimaging, small-animal bioimaging, multimodal bioimaging and time-resolved bioimaging is summarized. In addition, several possible future directions in this field are also discussed (133 references).