Effects of HIV-1 serostatus, HIV-1 RNA concentration, and CD4 cell count on the incidence of malaria infection in a cohort of adults in rural Malawi
Effects of HIV-1 serostatus, HIV-1 RNA concentration, and CD4 cell count on the incidence of malaria infection in a cohort of adults in rural Malawi
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DOI：
10.1086/432730
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发表时间：
2005-09-15
影响因子：
6.4
通讯作者：
Kublin, JG
中科院分区：
文献类型：
--
作者：
Patnaik, P;Jere, CS;Kublin, JG
背景。为了评估人类免疫缺陷病毒 (HIV) 感染对疟疾易感性的影响，我们在疟疾季节期间比较了 HIV 1 型 (HIV-1) 血清状态、基线血液 HIV-1 RNA 浓度和基线 CD4 细胞计数的疟疾发病率。方法。我们追踪了马拉维的 349 名成年人。对于 224 名 HIV-1 血清阳性成年人（占队列的 64%），我们测量了基线时的 HIV-1 RNA 浓度（n = 187）和 CD4 细胞计数（n = 184）。寄生虫血症 n=187 n=184 被定义为厚厚的血膜上存在无性寄生虫，并根据国家政策用磺胺多辛/乙胺嘧啶 (SP) 进行治疗。使用 Cox 回归估计寄生虫血症的风险比 (HR)。人口统计数据进行了调整。结果。 HIV-1 血清阳性与寄生虫血症相关（第一次寄生虫血症发作的调整后 HR，1.8 [95% CI，1.2 - 2.7]；第二次寄生虫血症发作 [第一次发作后 114 天] 调整后 HR，2.5 [95% CI，1.5 - 4.2]；调整后 HR，1.9 [95% CI，1.4 - 2.6]总体寄生虫血症）。治疗失败（寄生虫血症
Background. To assess the effects of human immunodeficiency virus (HIV) infection on susceptibility to malaria, we compared the incidence rates of malaria by HIV type 1 (HIV-1) serostatus, baseline blood HIV-1 RNA concentration, and baseline CD4 cell count, over the course of a malaria season.Methods. We followed a cohort of 349 adults in Malawi. For the 224 HIV-1-seropositive adults (64% of the cohort), we measured HIV-1 RNA concentration (n = 187) and CD4 cell count (n = 184) at baseline. Parasitemia n=187 n=184 was defined as presence of asexual parasites on a thick film of blood and was treated with sulfadoxine/pyrimethamine (SP), in accordance with national policy. Hazard ratios (HRs) of parasitemia were estimated using Cox regression. Demographics were adjusted for.Results. HIV-1 seropositivity was associated with parasitemia (adjusted HR, 1.8 [95% confidence interval {CI}, 1.2 - 2.7] for a first parasitemia episode; adjusted HR, 2.5 [95% CI, 1.5 - 4.2] for a second parasitemia episode [114 days after the first episode]; adjusted HR, 1.9 [95% CI, 1.4 - 2.6] for parasitemia overall). Treatment failure ( parasitemia