Remediation of cognitive deficits in schizophrenia.
Remediation of cognitive deficits in schizophrenia.
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精神分裂症认知缺陷的补救。
DOI：
10.1176/ajp.147.12.1650
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Podell,K
中科院分区：
文献类型：
--
作者：
Bellack,AS;Mueser,KT;Morrison,RL;Tierney,A;Podell,K
研究表明，精神分裂症的特征是背外侧前额叶皮层受损，阻止了一些基本信息处理任务的学习。为了验证这一假设，作者对16名住院精神分裂症患者进行了威斯康星州卡片分类测试，并进行了标准指导和偶然或非偶然强化。在每种条件下，性能都明显受损。第二组（N= 12）在接受指导加上排练和反馈后进行测试。这些受试者的表现与非患者规范相当，并在随后的一天保持不变。结果表明，在威斯康星州卡片分类测试的性能缺陷是可以补救的，无论他们是否是由于神经损伤。
Studies have suggested that schizophrenia is characterized by an impairment in the dorsolateral prefrontal cortex that prevents learning of some elementary information processing tasks. To test this hypothesis, the authors administered the Wisconsin Card Sorting Test to 16 schizophrenic inpatients with standard instructions and either contingent or noncontingent reinforcement. Performance was markedly impaired under each condition. A second cohort (N= 12) was tested after receiving instructions plus rehearsal and feedback. These subjects' performance was comparable to nonpatient norms and was maintained on a subsequent day. The results indicate that deficits in performance on the Wisconsin Card Sorting Test are remediable, whether or not they are due to neurological impairment.