Prolongation of the QT interval by ketanserin.
Prolongation of the QT interval by ketanserin.
复制标题
酮色林延长 QT 间期。
DOI：
10.1136/pgmj.64.748.112
复制
发表时间：
1988
影响因子：
5.1
通讯作者：
L. Ramsay
中科院分区：
文献类型：
--
作者：
H. A. Cameron;P. Waller;L. Ramsay
在高血压患者中，单剂量酮色林40 mg使校正的QT间期（QTc）延长至少8小时，2小时后最大增加35 ms（P <0.001，n = 6）。长期给药期间（20和40 mg b.d.）QTc分别延长46和45 ms。平均剂量73 mg/d治疗7周（n = 26）后的QTc延长与体重（r =-0.58，P <0.01）和经体重校正的酮色林剂量（r = 0.63，P <0.01）显著相关，但与酮色林、酮色醇、钾或钙的血浆浓度无关。高剂量酮色林（平均剂量167 mg/天，n = 9）使QTc延长40 ms（P <0.001），个别患者延长达80 ms。以临床使用的建议剂量（40-80 mg/天）使用酮色林治疗可能存在室性心律失常的风险。
In hypertensive patients single doses of ketanserin 40 mg prolonged the corrected QT interval (QTc) for at least 8 hours, with a maximal increase of 35 ms (P less than 0.001, n = 6) after 2 hours. During chronic dosing (20 and 40 mg b.d.) the QTc was further prolonged, by 46 and 45 ms respectively. QTc prolongation after treatment with a mean dose of 73 mg/day for 7 weeks (n = 26) was significantly related to body weight (r = -0.58, P less than 0.01), and to the dose of ketanserin corrected for body weight (r = 0.63, P less than 0.01), but not to plasma concentrations of ketanserin, ketanserinol, potassium or calcium. High doses of ketanserin (mean dose 167 mg/day, n = 9) increased the QTc by 40 ms (P less than 0.001), with prolongation of up to 80 ms in individual patients. Treatment with ketanserin at doses proposed for clinical use (40-80 mg/day) may carry a risk of ventricular arrhythmias.