Nematicidal Cardenolides from Nerium indicum Mill.
Nematicidal Cardenolides from Nerium indicum Mill.
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DOI：
10.1002/cbdv.200800011
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发表时间：
2009-03
影响因子：
2.9
通讯作者：
Xingbiao Wang;Guo-hong Li;Lijun Zheng;Kai-Yan Ji;Hua Lü;Fangfang Liu;L. Dang;M. Mo;Ke-Qin Zhang
中科院分区：
文献类型：
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作者：
Xingbiao Wang;Guo-hong Li;Lijun Zheng;Kai-Yan Ji;Hua Lü;Fangfang Liu;L. Dang;M. Mo;Ke-Qin Zhang
从凤尾草AcOEt提取液中分离得到3种杀线虫心硬素。通过生物测定引导分离。它们包括一种新的化合物，3 - o -（β -d -二羟基）-14,15 -二羟基-5 -卡-20(22)-烯内酯(1)，以及两种已知的化合物，uzarigenin(2)和cardenolide N-1(3)。化合物1 ~ 3对嗜木叶线虫、再毒线虫和秀丽隐杆线虫72 h的中位致死浓度（LC(50)）分别为103.3、49.0和45.4 mg l(-1), 257.0、62.7和177.8 mg l(-1), 242.9、29.1和41.7 mg l（-1）。本文首次报道了心桂枝内酯的杀线虫活性。
Three nematicidal cardenolides were obtained from the AcOEt extract of Nerium indicum Mill. by bioassay-guided fractionation. They include a new compound, 3beta-O-(beta-D-diginosyl)-14,15alpha-dihydroxy-5alpha-card-20(22)-enolide (1), and two known compounds, uzarigenin (2) and cardenolide N-1 (3). The median lethal concentrations (LC(50)) of compounds 1-3 against the nematodes Bursaphelenchus xylophilus, Panagrellus redivivus, and Caenorhabditis elegans at 72 h were 103.3, 49.0, and 45.4 mg l(-1), 257.0, 62.7, and 177.8 mg l(-1), and 242.9, 29.1, and 41.7 mg l(-1), respectively. This is the first report about the nematicidal activity of cardenolides.