A new method for removing artifacts from recordings of the electrically evoked compound action potential: Single-pulse stimulation.
A new method for removing artifacts from recordings of the electrically evoked compound action potential: Single-pulse stimulation.
复制标题
一种从电诱发复合动作电位记录中去除伪影的新方法：单脉冲刺激。
DOI：
10.1101/2024.01.17.24301435
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发表时间：
2024
期刊：
影响因子：
--
通讯作者：
He,Shuman
中科院分区：
文献类型：
--
作者：
Skidmore,Jeffrey;Yuan,Yi;He,Shuman
本文提出了一种去除单阴极双相脉冲刺激引起的电诱发复合动作电位（eCAP）中电伪影污染的新方法。新方法的发展是由人类人工耳蜗（CI）用户记录的结果所激发的，这些结果表明，在使用默认刺激参数时，在高刺激水平下测试的病例中，高达45%的病例违反了经典前向掩蔽伪影抑制技术的基本假设。随后，基于双曲线最能表征增产和记录过程中产生的伪影的发现，开发了一种新方法。用新方法得到的eCAP波形与用经典前向掩蔽技术记录的波形进行了比较。结果表明，在满足经典前向掩模基本假设的情况下，两种方法得到的eCAP波形具有可比性。相反，当违反经典前向掩蔽技术的基本假设时，两种方法得到的eCAP振幅差异显著，违反假设越多，eCAP振幅差异越大。新方法具有良好的重测信度（类内相关> 0.98）。总的来说，新方法是经典前向掩蔽技术的可行替代方案，可以获得CI用户单脉冲刺激诱发的无伪影ecap。
This report presents a new method for removing electrical artifact contamination from the electrically evoked compound action potential (eCAP) evoked by single cathodic-leading, biphasic-pulse stimulation. The development of the new method is motivated by results recorded in human cochlear implant (CI) users showing that the fundamental assumption of the classic forward masking artifact rejection technique is violated in up to 45% of cases tested at high stimulation levels when using default stimulation parameters. Subsequently, the new method developed based on the discovery that a hyperbola best characterizes the artifacts created during stimulation and recording is described. The eCAP waveforms obtained using the new method are compared to those recorded using the classic forward masking technique. The results show that eCAP waveforms obtained using both methods are comparable when the fundamental assumption of the classic forward masking technique is met. In contrast, eCAP amplitudes obtained using the two methods are significantly different when the fundamental assumption of the classic forward masking technique is violated, with greater differences in the eCAP amplitude for greater assumption violations. The new method also has excellent test-retest reliability (Intraclass correlation > 0.98). Overall, the new method is a viable alternative to the classic forward masking technique for obtaining artifact-free eCAPs evoked by single-pulse stimulation in CI users.