OUTBREAK OF HUMAN CALICIVIRUS GASTROENTERITIS IN A DAY-CARE-CENTER IN SYDNEY, AUSTRALIA
OUTBREAK OF HUMAN CALICIVIRUS GASTROENTERITIS IN A DAY-CARE-CENTER IN SYDNEY, AUSTRALIA
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DOI：
10.1128/jcm.29.3.544-550.1991
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发表时间：
1991-03-01
影响因子：
9.4
通讯作者：
MONROE, SS
中科院分区：
文献类型：
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作者：
GROHMANN, G;GLASS, RI;MONROE, SS
1988年1月至3月，澳大利亚新南威尔士州悉尼市一家日托中心的儿童和工作人员爆发了胃肠炎。 在11周的时间里，53人有101次胃肠炎发作;有些病人有5次单独的发作。 在有症状的儿童和工作人员粪便标本中，电镜检出率为32%，而无症状者仅为8%（P < 0.01）。 HCV的酶免疫分析和固相免疫电子显微镜证实。 HCV感染在婴儿中是一个特别的问题，他们具有最高的年龄特异性发作率，具有最大的症状/无症状感染比率，并且最有可能有第二次症状发作。 这种病毒的传播方式尚未确定，控制11周爆发的广泛努力收效甚微。 一些有症状的患者的HCV排泄延长和无症状感染的高比率可能导致了疫情持续时间的延长。 HCV可能是儿童胃肠炎的常见原因，但由于检测方法不敏感而未被认识到。
Between January and March 1988, an outbreak of gastroenteritis occurred among children and staff at a day-care center in Sydney, New South Wales, Australia. Over an 11-week period, 53 persons had 101 episodes of gastroenteritis; some patients had 5 separate episodes. The principal etiologic agent in the outbreak, human calicivirus (HCV), was detected by electron microscopy in 32% of fecal specimens from children and staff members with symptoms but only 8% of asymptomatic individuals (P < 0.01). HCV was confirmed by both an enzyme immunoassay and solid-phase immune electron microscopy. HCV infection was a particular problem in infants, who had the highest age-specific attack rates, had the greatest symptomatic/asymptomatic infection ratio, and were most likely to have a second symptomatic episode. The mode of transmission of this virus was not identified, and extensive efforts to control the 11-week outbreak had little effect. Prolonged excretion of HCV by some symptomatic patients and high rates of asymptomatic infection may have contributed to the extended duration of the outbreak. HCV may be a common cause of gastroenteritis in children that is underrecognized because of insensitive methods of detection.