Opposing Effects of Maternal Hypo- and Hyperthyroidism on the Stability of Thalamocortical Synapses in the Visual Cortex of Adult Offspring.
Opposing Effects of Maternal Hypo- and Hyperthyroidism on the Stability of Thalamocortical Synapses in the Visual Cortex of Adult Offspring.
复制标题
母亲甲状腺功能减退症和甲状腺功能亢进症对成年后代视觉皮层丘脑皮质突触稳定性的相反影响。
DOI：
10.1093/cercor/bhw096
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Coleman,JasonE
中科院分区：
文献类型：
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作者：
Strobl,Marie-ThereseJ;Freeman,Daniel;Patel,Jenica;Poulsen,Ryan;Wendler,ChristopherC;Rivkees,ScottA;Coleman,JasonE
在胎儿发育期间，甲状腺激素（TH）水平不足或过高会导致长期的神经和认知问题。对围产期甲状腺功能减退和甲状腺功能亢进动物模型的研究表明，这些问题可能是大脑皮层中适应不良回路形成的结果，这种情况可能持续到成年。在这里，我们使用母体甲状腺功能减退和甲状腺功能亢进的小鼠模型，以调查长期影响的甲状腺素（T4）水平在怀孕期间（相当于胚胎天6.5-18.5）丘脑皮质（TC）轴突动力学在成年后代。由于围产期甲状腺功能减退症已与人类视觉处理缺陷，我们进行了慢性双光子成像的TC轴突和终扣在初级视觉皮层（V1）。我们发现，母亲血清T4水平的降低或升高与成年后代V1期TC轴突和终扣的非典型稳态动力学相关。甲状腺功能减退的后代表现出轴突分支和终末动力学异常增加TC连接，而甲状腺功能亢进的后代的变化表明TC连接异常减少。总的来说，我们的数据表明，产前T4水平的改变会导致TC回路中的长期突触不稳定，这可能会损害视觉处理的早期阶段。
Insufficient or excessive thyroid hormone (TH) levels during fetal development can cause long-term neurological and cognitive problems. Studies in animal models of perinatal hypo- and hyperthyroidism suggest that these problems may be a consequence of the formation of maladaptive circuitry in the cerebral cortex, which can persist into adulthood. Here we used mouse models of maternal hypo- and hyperthyroidism to investigate the long-term effects of altering thyroxine (T4) levels during pregnancy (corresponding to embryonic days 6.5–18.5) on thalamocortical (TC) axon dynamics in adult offspring. Because perinatal hypothyroidism has been linked to visual processing deficits in humans, we performed chronic two-photon imaging of TC axons and boutons in primary visual cortex (V1). We found that a decrease or increase in maternal serum T4 levels was associated with atypical steady-state dynamics of TC axons and boutons in V1 of adult offspring. Hypothyroid offspring exhibited axonal branch and bouton dynamics indicative of an abnormal increase in TC connectivity, whereas changes in hyperthyroid offspring were indicative of an abnormal decrease in TC connectivity. Collectively, our data suggest that alterations to prenatal T4 levels can cause long-term synaptic instability in TC circuits, which could impair early stages of visual processing.