Family history and oral contraceptives unique relationships in breast cancer patients
Family history and oral contraceptives unique relationships in breast cancer patients
复制标题
乳腺癌患者的家族史和口服避孕药的独特关系
作者：
M. Black;C. S. Kwon;H. Leis;T. Barclay
根据乳腺癌患者既往口服避孕药（OC）的使用情况，确定了乳腺癌患者特定血亲中乳腺癌病史的相对频率。这些数据与来自各种类型的非侵入性乳腺病变患者和对照组妇女的数据进行了比较。研究发现，在连续使用OC一年或更长时间的乳腺癌患者中，祖母或阿姨的乳腺癌病史明显高于OC阴性乳腺癌患者，以及非侵入性乳腺病变患者和对照女性，无论OC使用情况如何。祖母或阿姨患有乳腺癌的乳腺癌患者使用OC的频率明显高于家族史（FH）阴性乳腺癌患者和仅限于祖母和阿姨以外亲属（母亲、姐妹篇、表兄弟姐妹）的乳腺癌患者。家族史似乎是OC使用与乳腺癌之间关系的重要协变量。有必要进行具体的研究来测试OC使用增加其祖母或阿姨患有乳腺癌的女性患乳腺癌风险的可能性，并降低FH阴性女性患乳腺癌的风险。
The relative frequency of a history of breast cancer among specific blood relatives was determined for breast cancer patients according to their prior use of oral contraceptives (OC). These data were compared with those derived from patients having various types of noninvasive breast lesions and from control women. It was found that a history of breast cancer among grandmothers or aunts was significantly more frequent among breast cancer patients who had used OC for one or more years continuously than among OC‐negative breast cancer patients, and among patients with noninvasive breast lesions and control women, regardless of OC usage. Breast cancer patients whose grandmothers or aunts had breast cancer used OC significantly more frequently than did family history (FH)‐negative breast cancer patients and breast cancer patients having a history of breast cancer limited to relatives other than grandmothers and aunts (mothers, sisters, cousins). It appears that the family history is a significant covariable in the relationship between OC usage and breast cancer. There is a need for specific studies to test the possibilities that OC usage increases the risk of breast cancer among women whose grandmothers or aunts had breast cancer, and reduces the risk of breast cancer in FH‐negative women.