Enhanced ordering of interacting filaments by molecular motors
Enhanced ordering of interacting filaments by molecular motors
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DOI：
10.1103/physrevlett.96.258103
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发表时间：
2006-06-30
影响因子：
8.6
通讯作者：
Kierfeld, Jan
中科院分区：
文献类型：
--
作者：
Kraikivski, Pavel;Lipowsky, Reinhard;Kierfeld, Jan
我们从理论上研究了运动性测定中细胞骨架细丝的合作行为，其中固定化的马达蛋白将细丝结合到基底表面，并积极地将它们沿着这些表面拉动。由于相互排斥的细丝，耦合动力学的细丝，电机头，和电机的尾巴，导致非平衡相变，概括的各向同性相变相应的平衡系统，硬杆流体。Langevin动力学模拟表明，运动活动增强的趋势，为有序化。我们开发了一个定量的理论作为电动机密度的函数的相边界的位置。在高分离力的电机，我们还观察到丝簇所产生的阻塞效应。
We theoretically study the cooperative behavior of cytoskeletal filaments in motility assays in which immobilized motor proteins bind the filaments to substrate surfaces and actively pull them along these surfaces. Because of the mutual exclusion of the filaments, the coupled dynamics of filaments, motor heads, and motor tails leads to a nonequilibrium phase transition which generalizes the isotropic-nematic phase transition of the corresponding equilibrium system, the hard-rod fluid. Langevin dynamics simulations show that the motor activity enhances the tendency for nematic ordering. We develop a quantitative theory for the location of the phase boundary as a function of motor density. At high detachment forces of motors, we also observe filament clusters arising from blocking effects.