Altered resting state functional network connectivity in children absence epilepsy
Altered resting state functional network connectivity in children absence epilepsy
复制标题
儿童失神癫痫静息状态功能网络连接的改变
DOI：
10.1016/j.jns.2015.04.054
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发表时间：
2015-07-15
影响因子：
4.4
通讯作者：
Yao, Dezhong
中科院分区：
文献类型：
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作者：
Li, Qifu;Cao, Weifang;Yao, Dezhong
功能连接的改变与癫痫活动的影响有关。连接异常，特别是在背侧注意（DAN），突出（SN）和默认模式（DMN）网络，可能导致癫痫发作期间意识丧失和儿童缺乏性癫痫（CAE）患者的认知缺陷。本研究的目的是确定功能性网络连接（FNC）是否在CAE患者和健康对照之间发生改变。采用独立分量分析方法，在18例CAE患者和21例健康对照者的静息状态功能磁共振成像数据集中鉴定出12个静息状态网络（rsn）。在控制年龄和性别影响的情况下，对FNC强度的组间差异进行了分析。结果表明，一些功能网络可分为两个亚群，亚群内相互关联，并相互拮抗。与对照组相比，CAE患者DMN、DAN和SN三个网络的FNC强度均出现异常。此外，两个亚组的拮抗作用发生了改变。这些结果可能反映了CAE中潜在的神经元功能损伤或这些rsn之间整合的改变，提示功能连接异常可能暗示了与癫痫活动累积影响相关的病理机制。这些发现有助于理解CAE的行为异常，如执行和注意功能紊乱以及失神发作时的意识丧失。(C) 2015 Elsevier B.V.版权所有
Altered functional connectivity has been associated with the influence of epileptic activity. Abnormalities in connectivity, particularly in dorsal attention (DAN), salience (SN) and default mode (DMN) networks, might contribute to the loss of consciousness during seizures and cognitive deficits in patients with children absence epilepsy (CAE). The objective of the present study was to identify whether the functional network connectivity (FNC) is changed between patients with CAE and healthy controls. Using independent component analysis, twelve resting state networks (RSNs) were identified in resting state functional magnetic resonance imaging data sets in eighteen CAE patients and twenty-one healthy controls. Analyses of the group differences in FNC strength were conducted, controlling for age and gender effects. The findings showed that some functional networks were clustered into two subgroups, correlated within subgroups and antagonized with each other. Compared with the controls, patients with CAE demonstrated abnormal FNC strength among three networks: DMN, DAN and SN. In addition, the antagonism of two subgroups was altered. These results might reflect the underlying neuronal functional impairment or altered integration among these RSNs in CAE, suggesting that the abnormal functional connectivity is likely to imply the pathological mechanism associated with the accumulative influence of epileptic activity. These findings contribute to the understanding of the behavior abnormality in CAE, such as disturbed executive and attentional functions and the loss of consciousness during absence seizures. (C) 2015 Elsevier B.V. All rights reserved.