Structuring of Abstract Working Memory Content by Fronto-parietal Synchrony in Primate Cortex
Structuring of Abstract Working Memory Content by Fronto-parietal Synchrony in Primate Cortex
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DOI：
10.1016/j.neuron.2018.07.025
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发表时间：
2018-08-08
期刊：
影响因子：
16.2
通讯作者：
Nieder, Andreas
中科院分区：
文献类型：
--
作者：
Jacob, Simon Nikolas;Haehnke, Daniel;Nieder, Andreas
在工作记忆中，不同区域的神经元活动是如何协调的，以允许多个刺激一起存储在工作记忆中，同时又保持独立，以便个人读出和保护免受干扰？使用配对记录在前额叶和顶叶皮层的猴子区分项目的数量（numerosities），我们发现，工作记忆的内容是由特定频率的振荡同步。β波段的顶叶-额叶信号传递着最近的数字输入信息。额顶叶耦合在theta波段区分多个记忆的数字。任务相关的和分散注意力的刺激嵌套在单个前额叶神经元的尖峰活动，但可以分开的阅读尖峰在顶叶θ振荡的不同阶段。相位锁定的强度，跨区域的记忆编码预测任务的表现。额顶网络中的频率特异性通信通道可以实现串行自下而上和并行自上而下的信息传输，为保护工作记忆免受干扰提供了重要机制。
How is neuronal activity across distant brain regions orchestrated to allow multiple stimuli to be stored together in working memory, yet maintained separate for individual readout and protection from distractors? Using paired recordings in the prefrontal and parietal cortex of monkeys discriminating numbers of items (numerosities), we found that working memory content is structured by frequency-specific oscillatory synchrony. Parieto-frontal signaling in the beta band carried information about the most recent numerical input. Fronto-parietal coupling in the theta band differentiated between multiple memorized numerosities. Task-relevant and distracting stimuli were nested in spiking activity of single prefrontal neurons, but could be separated by reading out spikes at distinct phases of parietal theta oscillations. The strength of phase-locked, cross-regional memory coding predicted task performance. Frequency-specific communication channels in the fronto-parietal network could enable serial bottom-up and parallel top-down information transmission, providing an important mechanism to protect working memory from interference.