Associations of serum ferritin and transferrin % saturation with all-cause, cancer, and cardiovascular disease mortality: Third National Health and Nutrition Examination Survey follow-up study.
Associations of serum ferritin and transferrin % saturation with all-cause, cancer, and cardiovascular disease mortality: Third National Health and Nutrition Examination Survey follow-up study.
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DOI：
10.3961/jpmph.2012.45.3.196
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发表时间：
2012-05
期刊：
影响因子：
--
通讯作者：
Lee DH
中科院分区：
文献类型：
--
作者：
Kim KS;Son HG;Hong NS;Lee DH
尽管实验研究表明铁可能参与氧化应激的产生，但关于体内铁储存标志物与心血管疾病或癌症之间关系的流行病学研究仍然存在争议。本研究旨在检查血清铁蛋白和转铁蛋白饱和度 (%TS) 与全因死亡率、癌症死亡率和心血管死亡率之间的关系。研究对象是1988-1994年第三次全国健康与营养检查调查中的50岁以上男性和绝经后女性。参与者的死亡率随访至 2006 年 12 月 31 日。无论是男性还是绝经后女性，血清铁蛋白与全因死亡率、癌症死亡率或心血管死亡率均无关。然而，全因死亡率、癌症死亡率和心血管死亡率与男性的 %TS 呈负相关。与最低五分位的男性相比，全因死亡率、癌症死亡率和心血管死亡率的调整后风险比分别为 0.85、0.86、0.76 和 0.74（趋势 p < 0.01）、0.82、0.73、0.75 和 0.63（趋势 p < 0.01）以及 0.86、0.81、0.72，和 0.76（趋势 p < 0.01）。对于绝经后妇女，还观察到全因死亡率和心血管死亡率呈负相关，但癌症死亡率仅在 %TS 的第二个五分位数中与第一个五分位数相比显着较低。与实验研究中对铁作用的推测不同，%TS 与男性和绝经后女性的全因死亡率、癌症死亡率和心血管死亡率呈负相关。另一方面，血清铁蛋白与全因死亡率、癌症死亡率或心血管死亡率无关。
Even though experimental studies have suggested that iron can be involved in generating oxidative stress, epidemiologic studies on the association of markers of body iron stores with cardiovascular disease or cancer remain controversial. This study was performed to examine the association of serum ferritin and transferrin saturation (%TS) with all-cause, cancer, and cardiovascular mortality. The study subjects were men aged 50 years or older and postmenopausal women of the Third National Health and Nutrition Examination Survey 1988-1994. Participants were followed-up for mortality through December 31, 2006. Serum ferritin was not associated with all-cause, cancer, or cardiovascular mortality for either men or postmenopausal women. However, all-cause, cancer, and cardiovascular mortality were inversely associated with %TS in men. Compared with men in the lowest quintile, adjusted hazard ratios for all-cause, cancer, and cardiovascular mortality were 0.85, 0.86, 0.76, and 0.74 (p for trend < 0.01), 0.82, 0.73, 0.75, and 0.63 (p for trend < 0.01), and 0.86, 0.81, 0.72, and 0.76 (p for trend < 0.01), respectively. For postmenopausal women, inverse associations were also observed for all-cause and cardiovascular mortality, but cancer mortality showed the significantly lower mortality only in the 2nd quintile of %TS compared with that of the 1st quintile. Unlike speculation on the role of iron from experimental studies, %TS was inversely associated with all-cause, cancer and cardiovascular mortality in men and postmenopausal women. On the other hand, serum ferritin was not associated with all-cause, cancer, or cardiovascular mortality.