α1- and β-adrenergic receptors in brown adipose tissue of lean (Fa/?) and obese (fa/fa) Zucker rats. Effects of cold-acclimation, sucrose feeding and adrenalectomy
α1- and β-adrenergic receptors in brown adipose tissue of lean (Fa/?) and obese (fa/fa) Zucker rats. Effects of cold-acclimation, sucrose feeding and adrenalectomy
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瘦 (Fa/?) 和肥胖 (fa/fa) Zucker 大鼠棕色脂肪组织中的 α1- 和 β- 肾上腺素受体。冷驯化、蔗糖喂养和肾上腺切除术的影响。
DOI：
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发表时间：
1988
期刊：
影响因子：
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通讯作者：
D. York
中科院分区：
文献类型：
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作者：
A. Raasmaja;D. York
1. 用[3H]prazosin和[3H]CGP-12177分别研究了遗传性肥胖Zucker大鼠棕色脂肪组织(BAT) α -1和β -肾上腺素能受体的数量（fa/fa）。2. 2-4月龄和6周龄时，肥胖Zucker大鼠的BAT α 1-肾上腺素能受体密度明显低于瘦弱Zucker大鼠。6周龄的肥胖和瘦弱Zucker大鼠的β -肾上腺素能受体密度相同。3. 冷驯化显著增加了瘦型和肥胖型Zucker大鼠BAT中α 1受体的密度，β受体的数量也有所增加。4. 蔗糖饲喂对瘦型和肥胖型Zucker大鼠BAT中α 1受体的密度没有影响，但增加了β受体的密度。5. 肾上腺切除术使肥胖Zucker大鼠的肾上腺素能受体密度恢复到瘦鼠的水平。6. 结果表明，α 1受体密度与组织募集有直接关系，α 1受体密度与交感神经活动呈正相关。受体密度显然与饲养条件有更好的相关性。
1. The populations of alpha 1- and beta-adrenergic receptors in brown adipose tissue (BAT) of genetically obese Zucker rats (fa/fa) were studied with [3H]prazosin and [3H]CGP-12177 respectively. 2. The density of alpha 1-adrenergic receptors in BAT was significantly lower in obese than in lean Zucker rats, both at 2-4 months of age and at 6 weeks of age. The density of beta-adrenergic receptors was identical in BAT of lean and obese 6-week-old Zucker rats. 3. Cold-acclimation increased the alpha 1-receptor density significantly in BAT of both lean and obese Zucker rats, and the number of beta-receptors was also somewhat increased. 4. Sucrose feeding did not affect the density of alpha 1-receptors in BAT of lean or obese Zucker rats, but it increased beta-receptor density. 5. Adrenalectomy restored the density of alpha 1-adrenergic receptors in BAT of obese Zucker rats to the value observed in lean rats. 6. It is concluded that there is a direct correlation between alpha 1-receptor density and tissue recruitment, and that alpha 1-receptor density is thus positively correlated with sympathetic activity. beta-Receptor density is apparently better correlated with feeding conditions.