Prevalence of allergy and anaphylactic symptoms in 210 adult and pediatric patients with mastocytosis in Spain:: a study of the Spanish network on mastocytosis (REMA)
Prevalence of allergy and anaphylactic symptoms in 210 adult and pediatric patients with mastocytosis in Spain:: a study of the Spanish network on mastocytosis (REMA)
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DOI：
10.1111/j.1365-2222.2007.02804.x
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发表时间：
2007-10-01
影响因子：
6.1
通讯作者：
Mora, L. Escribano
中科院分区：
文献类型：
--
作者：
de Olano, D. Gonzalez;Caballer, B. de la Hoz;Mora, L. Escribano
背景肥大细胞（Mast cell，MCs）通过释放炎症介质而在变态反应性疾病中发挥重要作用。肥大细胞增多症的特征是肥大细胞的异常增殖和积聚，其中介质被不连续地或持续地释放。方法对210例肥大细胞增多症患者进行问卷调查，了解其哮喘、鼻炎、结膜炎、过敏性鼻炎等过敏性疾病的发生情况，并对过敏性疾病的发生情况进行分析。特应性皮炎、荨麻疹和过敏反应。患者接受总IgE、Phadiatop（（R））婴儿（空气过敏原和食物过敏原）、乳胶特异性IgE和单纯异尖线虫特异性IgE测定。结果过敏反应的患病率为23.9%，过敏反应的临床症状与特异性IgE有关。过敏患者血清总IgE水平显著高于非过敏患者（中位数58 vs.16.5kU/L，P < 0.0001）。36名患者（22%）出现过敏症状，其中9名患者确定了过敏原。男性患者的变态反应和过敏性症状明显多于女性患者（分别为61.5%和38.5%; 72%和28%）。过敏症状在肥大细胞增多症男性和IgE升高的患者中更为普遍。胶囊摘要肥大细胞增多症的过敏患病率与一般人群相似。过敏性症状在男性和IgE升高的患者中更常见。特应性共存不影响肥大细胞增多症相关症状。
Background Mast cells (MCs) play a key role in allergic diseases through the release of inflammatory mediators, which are responsible of allergic symptoms. Mastocytosis is characterized by an abnormal proliferation and accumulation of mast cells, in which mediators are released intermittingly or continuously. Despite these clinical similarities, few studies have addressed the presence of allergic symptoms in mastocytosis patients, including anaphylaxis.Objective A prospective evaluation was carried out to study the prevalence of allergic diseases in patients with mastocytosis and their impact on the natural history of mastocytosis.Methods A questionnaire was given to 210 patients with mastocytosis to evaluate the history of asthma, rhinitis, conjunctivitis, atopic dermatitis, urticaria and anaphylaxis. Patients underwent total IgE, Phadiatop((R)) infant (aeroallergens and food allergens), specific IgE to latex and to Anisakis simplex determinations. Skin tests were done to 72 patients.Results The prevalence of allergy, as defined by clinical symptoms associated to specific IgE, was 23.9%. Total IgE level was significantly higher in patients with allergy as compared with patients without allergy (median 58 vs. 16.5 kU/L, P < 0.0001). Anaphylactic symptoms were present in 36 patients (22%), in nine the allergen was identified. Males had more allergy and anaphylactic symptoms than females (61.5% vs. 38.5% and 72% vs. 28%, respectively).Conclusion Allergic diseases coexist in patients with mastocytosis with similar frequency as compared with the general population. Anaphylactic symptoms are more prevalent in males with mastocytosis and in patients with elevated IgE.Capsule summary The prevalence of allergy in mastocytosis is similar to the general population. Anaphylactic symptoms are more prevalent in males and in patients with elevated IgE. The coexistence of atopy does not influence mastocytosis-associated symptoms.