IMMUNOSUPPRESSIVE EFFECT OF BREDININ ON CELL-MEDIATED AND HUMORAL IMMUNE-REACTIONS IN EXPERIMENTAL-ANIMALS
IMMUNOSUPPRESSIVE EFFECT OF BREDININ ON CELL-MEDIATED AND HUMORAL IMMUNE-REACTIONS IN EXPERIMENTAL-ANIMALS
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DOI：
10.1097/00007890-198302000-00007
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发表时间：
1983-01-01
期刊：
影响因子：
6.2
通讯作者：
KASHIWAGI, N
中科院分区：
文献类型：
--
作者：
KAMATA, K;OKUBO, M;KASHIWAGI, N
Bredinin (BR) 是一种从布雷菲尔德真青霉 (Eupenicillium brefeldianum) 中分离出来的咪唑核苷，此前曾有报道称可以延长狗同种异体肾移植物的存活率。在实验动物中研究了 BR 的免疫抑制作用。在比格犬中，体外 BR 处理抑制了有丝分裂原或同种异体细胞刺激的淋巴细胞的体外反应。体内给予的 BR 还显示出对豚鼠结核杆菌迟发性超敏反应的抑制作用，或对兔子注射增强 SRBC（绵羊红细胞）后血凝素产生的抑制作用。 BR 具有与硫唑嘌呤相当的免疫抑制效力，并且与后者相比显示出较低的肝毒性。
Bredinin (BR), an imidazole nucleoside isolated from Eupenicillium brefeldianum was previously reported to prolong kidney allograft survival in dogs. The immunosuppressive effect of BR was studied in experimental animals. In beagles, in vitro responses of lymphocytes stimulated by mitogens or allogeneic cells were suppressed by in vitro BR treatment. BR, given in vivo, also showed an inhibitory action against development of delayed hypersensitivity reaction to tubercle bacilli in guinea pigs or against hemagglutinin production following booster SRBC [sheep red blood cells] injection in rabbits. BR had an immunosuppressive potency comparable to that of azathioprine and showed a decreased hepatotoxicity compared with the latter.