SF-36 summary and subscale scores are reliable outcomes of neuropsychiatric events in systemic lupus erythematosus
SF-36 summary and subscale scores are reliable outcomes of neuropsychiatric events in systemic lupus erythematosus
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DOI：
10.1136/ard.2010.138792
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发表时间：
2011-06-01
影响因子：
27.4
通讯作者：
Farewell, V.
中科院分区：
文献类型：
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作者：
Hanly, J. G.;Urowitz, M. B.;Farewell, V.
目的探讨系统性红斑狼疮(SLE)患者健康相关生活质量的变化与神经精神事件临床结局的关系。方法对新诊断的系统性红斑狼疮(SLE)患者的神经精神事件进行评估。事件的结果由医生完成的七分量表确定，并与患者完成的简短表格36(SF-36)健康调查问卷进行比较。结果在1400个队列中，274名患者(92%为女性，68%为高加索人)有一次或多次神经精神事件，两次评估的间隔为12.3+/-2个月。SF-36心理成分总分(MCS)总分在两次就诊期间的变化差异有统计学意义(P
Objective To examine change in health-related quality of life in association with clinical outcomes of neuropsychiatric events in systemic lupus erythematosus (SLE).Methods An international study evaluated newly diagnosed SLE patients for neuropsychiatric events attributed to SLE and non-SLE causes. The outcome of events was determined by a physician-completed seven-point scale and compared with patient-completed Short Form 36 (SF-36) health survey questionnaires. Statistical analysis used linear mixed-effects regression models with patient-specific random effects.Results 274 patients (92% female; 68% Caucasian), from a cohort of 1400, had one or more neuropsychiatric event in which the interval between assessments was 12.3+/-2 months. The overall difference in change between visits in mental component summary (MCS) scores of the SF-36 was significant (p