Macrophages, as a Promising Strategy to Targeted Treatment for Colorectal Cancer Metastasis in Tumor Immune Microenvironment.
Macrophages, as a Promising Strategy to Targeted Treatment for Colorectal Cancer Metastasis in Tumor Immune Microenvironment.
复制标题
巨噬细胞作为肿瘤免疫微环境中结直肠癌转移靶向治疗的一种有前景的策略
DOI：
10.3389/fimmu.2021.685978
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发表时间：
2021
影响因子：
7.3
通讯作者：
Wang Y
中科院分区：
文献类型：
--
作者：
Zhang Y;Zhao Y;Li Q;Wang Y
肿瘤免疫微环境在结直肠癌的转移中起着至关重要的作用。作为最重要的免疫细胞之一，巨噬细胞充当吞噬细胞，在组织周围巡逻，清除入侵的病原体和细胞碎片，维持组织稳态。值得注意的是，巨噬细胞具有高度可塑性的特点，可以根据不同的功能分为不同的亚型，可以在不同类型的分子和信号通路诱导下进行相互的表型转换。巨噬细胞通过改变肿瘤免疫微环境来调节结直肠癌的发展和转移潜力。在肿瘤组织中，肿瘤相关巨噬细胞通常在肿瘤免疫微环境中发挥促癌作用，同时也与不良预后相关。本文综述了巨噬细胞在结直肠癌转移过程中的机制和刺激因素，旨在表明靶向巨噬细胞可能是结直肠癌治疗的一个有前景的策略。
The tumor immune microenvironment plays a vital role in the metastasis of colorectal cancer. As one of the most important immune cells, macrophages act as phagocytes, patrol the surroundings of tissues, and remove invading pathogens and cell debris to maintain tissue homeostasis. Significantly, macrophages have a characteristic of high plasticity and can be classified into different subtypes according to the different functions, which can undergo reciprocal phenotypic switching induced by different types of molecules and signaling pathways. Macrophages regulate the development and metastatic potential of colorectal cancer by changing the tumor immune microenvironment. In tumor tissues, the tumor-associated macrophages usually play a tumor-promoting role in the tumor immune microenvironment, and they are also associated with poor prognosis. This paper reviews the mechanisms and stimulating factors of macrophages in the process of colorectal cancer metastasis and intends to indicate that targeting macrophages may be a promising strategy in colorectal cancer treatment.
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