Evidence of GABAergic modulation in melatonin-induced short-term memory deficits and food consumption.
Evidence of GABAergic modulation in melatonin-induced short-term memory deficits and food consumption.
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DOI：
10.1358/mf.1998.20.4.485685
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发表时间：
1998-05
影响因子：
--
通讯作者：
Shaji Av;Kulkarni Sk
中科院分区：
文献类型：
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作者：
Shaji Av;Kulkarni Sk
褪黑激素的许多药理作用已被发现与苯二氮卓类药物相似。本研究分析了褪黑素对高架十字迷宫迁移潜伏期和摄食行为的短时记忆提取的影响，并与地西泮进行了比较。褪黑激素剂量依赖性地（10-100 mg/kg）产生短期记忆缺陷，并增强地西泮（1 mg/kg）诱导的小鼠认知缺陷。氟马西尼（1和4 mg/kg）可逆转褪黑素对地西泮诱导的记忆障碍的增强作用。长期治疗与褪黑激素（10 mg/kg/7天）产生了类似的配置文件，在高架十字迷宫的转移潜伏期相比，地西泮。在食物消费行为研究中，与对照相比，褪黑激素（25和50 mg/kg）产生了显著的超噬作用。氟马西尼（4 mg/kg）能显著地逆转地西泮（2 mg/kg）引起的摄食量增加，但对褪黑素引起的摄食量增加无明显影响。这些发现进一步证明褪黑激素的某些药理作用与地西泮相当，可能涉及中枢GABA能机制。
Many of the pharmacological effects of melatonin have been found to be similar to those of benzodiazepines. In the present study, we analyzed the role of melatonin on short-term memory retrieval on transfer latency in elevated plus maze and food consumption behavior, and the effects were compared with those of diazepam. Melatonin dose-dependently (10-100 mg/kg) produced short-term memory deficit and it potentiated diazepam- (1 mg/kg) induced cognitive deficit in mice. Flumazenil (1 and 4 mg/kg) could reverse enhancement in diazepam-induced memory deficit by melatonin. Chronic treatment with melatonin (10 mg/kg/7d) produced a similar profile in transfer latency on elevated plus maze compared with that of diazepam. In a food consumption behavior study, melatonin (25 and 50 mg/kg) produced a significant hyperphagic effect compared to control. Flumazenil (4 mg/kg) could significantly reverse the hyperphagic effects induced by diazepam (2 mg/kg), but would be insignificant with regard to that due to melatonin. These findings provide further evidence that some of the pharmacological effects of melatonin are comparable with those of diazepam and may involve central GABAergic mechanism.