INTERGENERATIONAL STUDIES OF HUMAN BIRTH-WEIGHT FROM THE 1958 BIRTH COHORT .1. EVIDENCE FOR A MULTIGENERATIONAL EFFECT
INTERGENERATIONAL STUDIES OF HUMAN BIRTH-WEIGHT FROM THE 1958 BIRTH COHORT .1. EVIDENCE FOR A MULTIGENERATIONAL EFFECT
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DOI：
10.1111/j.1471-0528.1992.tb14396.x
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发表时间：
1992-01-01
期刊：
影响因子：
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通讯作者：
EVANS, SJW
中科院分区：
文献类型：
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作者：
EMANUEL, I;FILAKTI, H;EVANS, SJW
目的探讨多代同堂对出生体重的影响。设计资料来自1958年英国国家儿童发展研究中一周出生至23岁的纵向研究。这些提供的社会生物学信息的父母的队列，队列成员从出生起，怀孕和出生体重的任何婴儿出生的队列成员。主要结果measure主要结果是出生的婴儿的出生体重的队列成员，为他们提供完整的代际数据为1638首生。多元回归模型被用来调查他们的出生体重和他们的父母和祖父母的特征之间的任何关联。结果婴儿的出生体重和父母的出生体重，但不是孕龄之间发现显着的正相关。对于女性队列成员所生的婴儿，额外的发现包括他们的出生体重与外祖母的身高和外祖父的社会阶层之间的关联，即使在调整了出生体重的强预测因素如母亲体重之后，结论这些结果支持了出生体重通过母亲传递的多代影响线
Objective To investigate possible multigenerational influences on birthweight.Design Data from the longitudinal study of one week's births in 1958 up to the age of 23 years, the British National Child Development Study, were utilized. These provide socio-biological information on the parents of the cohort, on the cohort members from birth onwards, and on the pregnancies and the birthweight of any babies born to the cohort members.Main outcome measure The main outcome was the birthweight of babies born to the cohort members, for whom complete intergenerational data were available for 1638 firstborn. Multiple regression modelling was used to investigate any associations between their birthweight and characteristics of their parents and grandparents.Results Significant positive associations were found between babies' birthweight and parental birthweight but not gestational age. For the babies born to female cohort members additional findings included associations between their birthweight and the height of the maternal grandmother and the social class of the maternal grandfather, even after adjustment for such strong predictors of birthweight as maternal weight, smoking habit in pregnancy and baby's sex and birth order.Conclusion These results thus offer support for a multigenerational influence on birthweight passed through the maternal line.