Factors associated with the severity of delirium
Factors associated with the severity of delirium
复制标题
与谵妄严重程度相关的因素
DOI：
10.1002/hup.2787
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Ozaki N
中科院分区：
文献类型：
--
作者：
Tachibana M;Inada T;Ichida M;Kojima S;Shioya M;Wakayama K;Ozaki N
背景影响妄想发展的各种因素已被确认。然而，精神错乱的严重程度和潜在的相关因素之间的联系还没有得到充分的研究。本研究旨在探讨与精神障碍严重程度相关的因素及可逆性影响因素。方法选择2015年5月至2020年4月在某综合医院精神科就诊的577例精神分裂症患者。采用妄想评定量表-98修订版(DRS-R-98)评定妄想的严重程度。结果重症监护病房入院(p=0.003)、苯二氮卓类药物的使用(p=0.01)、痴呆(p=0.02)和高龄(p=0.045)均与妄想的严重程度呈正相关，而β受体阻滞剂的使用(p=0.045)与妄想的严重程度呈负相关。结论应尽量避免使用可逆转的致病因素，即苯二氮卓类药物的使用，尤其是在老年、痴呆或需要重症监护的患者。减少苯二氮类药物的剂量或改用其他药物应该是优先事项。
BackgroundVarious factors affecting the development of delirium have been identified. However, the associations between the severity of delirium and potentially related factors have not been adequately investigated. The aim of the present study was to explore factors associated with the severity of delirium and to identify the reversible contributing factors.MethodsA total of 577 patients with delirium referred to the Department of Psychiatry during the 5 years from May 2015 to April 2020 at a general hospital were included. The Delirium Rating Scale‐revised‐98 (DRS‐R‐98) was used to measure the severity of delirium. Multiple regression analysis was used to determine whether individual factors were associated with the severity of delirium.ResultsIntensive care unit admission (p= 0.003), use of benzodiazepines (p= 0.01), dementia (p= 0.02), and older age (p= 0.045) were all positively associated the severity of delirium, while use ofβ‐blockers (p= 0.001) was negatively associated with the severity of delirium.ConclusionsReversible contributing factors, that is use of benzodiazepines, should be avoided as much as possible, especially in elderly patients or patients with dementia or patients who need critical care in ICU. Reducing the dose of benzodiazepines or switching them to other drugs should be a priority.