The CTSA as an Exemplar Framework for Developing Multidisciplinary Translational Teams
The CTSA as an Exemplar Framework for Developing Multidisciplinary Translational Teams
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DOI：
10.1111/cts.12004
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发表时间：
2013-02-01
影响因子：
3.9
通讯作者：
Brasier, Allan R.
中科院分区：
文献类型：
--
作者：
Calhoun, William J.;Wooten, Kevin;Brasier, Allan R.
转化科学需要来自多个学科的科学家共同努力，以改善人类疾病的预防，诊断和治疗。虽然存在的文献设计和管理的多学科团队，很少有人写的多学科翻译团队（MTTs）。MTT是不同的混合实体，其目标来自行业和学术模型。我们确定了30个设计因素在10个领域的文献调查相关的MTT模型：具体的目标，结构和过程。这些方面进行了调整，以适应我们自己的制度环境中的选择和管理的11个MTT，利用得克萨斯大学医学分支（UTMB）临床和转化科学奖（CTSA）的资源。两个具体多边贸易条约的案例说明了在教育和科学进步方面遇到的一些挑战和实现的机会。学科性的网络描述表明，CTSA KRs和CTSA的领导有助于学科多样性，特别是在小（或新生）MTTs。对MTT-KR利用率的单独描述表明，MTT大量利用数据分析、转化技术和新方法，而其他KR则为基础设施开发做出了重大贡献。我们的结论是，CTSA可以提供一个丰富的基础设施框架和科学环境，成功的MTTs的发展。《临床和运输科学》2013年;第6卷：6071
Translational science requires that scientists from multiple disciplines work together to improve the prevention, diagnosis, and treatment of human disease. Although a literature exists on the design and management of multidisciplinary teams, little has been written on multidisciplinary translational teams (MTTs). MTTs are distinct hybrid entities, with goals taken from both industry and academic models. We identified 30 design factors in 10 domains from a literature survey relevant to our MTT model: specific goals, structures, and processes. These dimensions were adapted to our own institutional environment in the selection and management of 11 MTTs that exploited resources of University of Texas Medical Branch (UTMB) Clinical and Translational Sciences Awards (CTSA). Case illustrations of two specific MTTs illustrate some of the challenges encountered and opportunities realized in terms of education and scientific advances. Network depiction of disciplinarity indicated that CTSA KRs and CTSA leadership contributed to discipline diversity especially in small (or nascent) MTTs. A separate depiction of MTT-KR utilization indicated that data analysis, translational technologies, and novel methods were heavily utilized by MTTs, whereas other KRs contributed significant effort to infrastructure development. We conclude that the CTSA can provide a rich infrastructural framework and scientific environment for the development of successful MTTs. Clin Trans Sci 2013; Volume 6: 6071