Shared brain areas but not functional connections controlling movement timing and order
Shared brain areas but not functional connections controlling movement timing and order
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DOI：
10.1523/jneurosci.0340-05.2005
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发表时间：
2005-06-01
影响因子：
5.3
通讯作者：
Hallett, M
中科院分区：
文献类型：
--
作者：
Garraux, G;McKinney, C;Hallett, M
事实上，人类大量行为的每一个方面都嵌入了序列背景中，但是，作为一个给定目标的函数，对定义运动序列（一系列运动的顺序和间隔）的两个基本维度的调整的大脑机制却知之甚少。使用功能磁共振成像，我们证明，在神经元水平上，这些任务只能通过共同激活的关联区域之间的功能相互作用的差异来区分，其中包括双侧皮质下-顶叶-额叶区域和两个皮质下结构。在这些共享的关联领域的活动，优先耦合在右壳核在操作的时间和操作的串行顺序与在右后小脑。这一发现很重要，因为它为运动序列的认知控制过程中大脑的有效组织提供了证据，并支持了最近提出的一个原则，根据该原则，参与不同行为任务的大脑区域的作用，在其测量活动中没有差异变化，取决于它们与其他连接区域的相互作用的变化，作为任务的函数。
Virtually every aspect of the enormous repertoire of human behaviors is embedded in a sequential context, but brain mechanisms underlying the adjustment of two fundamental dimensions defining a motor sequence (order of a series of movements and intervals separating them) as a function of a given goal are poorly understood. Using functional magnetic resonance imaging, we demonstrate that, at the neuronal level, these tasks can only be distinguished by differences in functional interactions between associative areas of common activation, which included bilateral subcortico-parieto-frontal regions, and two subcortical structures. Activity in these shared associative areas was preferentially coupled with that in right putamen during manipulation of timing and with that in right posterior cerebellum during manipulation of serial order. This finding is important because it provides evidence for an efficient organization of the brain during cognitive control of motor sequences and supports a recently proposed principle according to which the role of brain regions involved in different behavioral tasks without differential alterations in their measured activity depends on changes in their interactions with other connected areas as a function of the tasks.