Preliminary evidence for a beneficial effect of low‐frequency, repetitive transcranial magnetic stimulation in patients with major depression and schizophrenia
Preliminary evidence for a beneficial effect of low‐frequency, repetitive transcranial magnetic stimulation in patients with major depression and schizophrenia
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低频重复经颅磁刺激对重度抑郁症和精神分裂症患者有益的初步证据
DOI：
10.1002/(sici)1520-6394(1998)7:2
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发表时间：
1998
影响因子：
7.4
通讯作者：
E. Klein
中科院分区：
文献类型：
--
作者：
M. Feinsod;B. Kreinin;A. Chistyakov;E. Klein
本研究旨在评估低频重复经颅磁刺激（rTMS）对重度抑郁症和精神分裂症患者的潜在疗效。实验设计：我们研究了14名重度抑郁症患者和10名精神分裂症患者的10次rTMS疗程的治疗效果。主要观察：7名抑郁症患者报告抑郁症状有显著改善，7名精神分裂症患者报告焦虑和不安有所改善。结论：这些初步结果表明，低频rTMS可能主要对MD有益，在一定程度上对精神分裂症有益，并支持需要对照研究来进一步验证其治疗潜力。抑郁和焦虑(7):65 - 68,1998。©1998 Wiley‐Liss, Inc。
This study was designed to evaluate the potential efficacy of repetitive transcranial magnetic stimulation (rTMS) at low‐frequency in patients with major depression and schizophrenia. Experimental Design: We investigated the therapeutic effect of a course of 10 rTMS sessions in 14 subjects with major depression (MD) and 10 with schizophrenia. Principal Observations: Seven of the depressed patients reported significant improvement in depressive symptomatology, and seven of the schizophrenic subjects reported amelioration of anxiety and restlessness. Conclusions: These preliminary results suggest that low‐frequency rTMS may be beneficial mainly in MD and to some extent in schizophrenia, and support the need for controlled studies to further validate its therapeutic potential. Depression and Anxiety 7:65–68, 1998. © 1998 Wiley‐Liss, Inc.