Lack of orientation and direction selectivity in a subgroup of fast-spiking inhibitory interneurons: cellular and synaptic mechanisms and comparison with other electrophysiological cell types.
Lack of orientation and direction selectivity in a subgroup of fast-spiking inhibitory interneurons: cellular and synaptic mechanisms and comparison with other electrophysiological cell types.
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DOI：
10.1093/cercor/bhm137
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发表时间：
2008-05
期刊：
影响因子：
3.7
通讯作者：
L. Nowak;Maria V. Sanchez-Vives;D. McCormick
中科院分区：
文献类型：
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作者：
L. Nowak;Maria V. Sanchez-Vives;D. McCormick
cat区17的神经元可分为4种不同的电生理细胞类别（常规尖峰，内在爆裂，颤振和快速尖峰[FS]）。然而，对这些不同细胞类别的功能特性知之甚少。在这里，我们比较了cat区17中这些细胞类别之间的定向和方向选择性，发现FS抑制性神经元的一个子集，通常具有复杂的感受野，与其他细胞类型相比，表现出很少的选择性。在对最佳视觉刺激作出反应时，γ -范围膜波动的发生和幅度以及动作电位的数量上的差异，与在定向和方向选择性上观察到的差异并不平行。相反，选择性的差异主要是由于膜电位反应调节的差异，尽管脉冲阈值的变化也有贡献：与其他细胞类别相比，弱选择性FS神经元表现出较低的脉冲阈值和更广泛的膜电位反应调节。我们的结果与一种假设是一致的，即一组FS神经元接受连接并具有允许产生弱选择性反应的内在特性。弱选择性抑制神经元的存在与依赖于广泛调节抑制的定向选择性模型是一致的。
Neurons in cat area 17 can be grouped in 4 different electrophysiological cell classes (regular spiking, intrinsically bursting, chattering, and fast spiking [FS]). However, little is known of the functional properties of these different cell classes. Here we compared orientation and direction selectivity between these cell classes in cat area 17 and found that a subset of FS inhibitory neurons, usually with complex receptive fields, exhibited little selectivity in comparison with other cell types. Differences in occurrence and amplitude of gamma-range membrane fluctuations, as well as in numbers of action potentials in response to optimal visual stimuli, did not parallel differences observed for orientation and direction selectivity. Instead, differences in selectivity resulted mostly from differences in tuning of the membrane potential responses, although variations in spike threshold also contributed: weakly selective FS neurons exhibited both a lower spike threshold and more broadly tuned membrane potential responses in comparison with the other cell classes. Our results are consistent with the hypothesis that a subgroup of FS neurons receives connections and possesses intrinsic properties allowing the generation of weakly selective responses. The existence of weakly selective inhibitory neurons is consistent with orientation selectivity models that rely on broadly tuned inhibition.