Microvascular abnormalities in dry eye patients
Microvascular abnormalities in dry eye patients
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干眼症患者的微血管异常
DOI：
10.1016/j.mvr.2018.03.015
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发表时间：
2018-07-01
影响因子：
3.1
通讯作者：
Yuan, Jin
中科院分区：
文献类型：
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作者：
Chen, Wan;Deng, Yuqing;Yuan, Jin
本研究旨在评价干眼症（DED）患者结膜血流速度和微血管网密度。招募了25名DED患者和25名健康对照。右眼颞部球结膜微血管和微循环使用功能裂隙灯生物显微镜进行评估。血管参数包括血流速度（BFV）、血流速率（BFR）、微血管网密度和血管直径。使用盒计数法进行分形分析以测量代表血管密度的分形维数（Dbox）。DEL组的延髓BFV为0.59 ± 0.09 mm/s，对照组为0.47 ± 0.12 mm/s（P < 0.001）。DED组的BFR为169.5 +/- 1.8，而对照组为107.2 +/- 49.6（P < 0.001）。DED患者的Dbox（1.65 ± 0.04）高于对照组（1.60 ± 0.07，P < 0.05）。此外，DED组的血管直径（21.8 ± 1.8 μ m）大于对照组（17.9 ± 2.2 μ m，P < 0.001）。DED患者的Dbox与眼表疾病指数（OSDI）呈正相关（r = 0.54，P = 0.008）。DED患者球结膜微血管改变，包括血流速度增加，血管密度增加，血管直径增大。
This study was conducted to evaluate conjunctival blood flow velocities and microvascular network density in patients with dry eye disease (DED). Twenty-five patients with DED and 25 healthy controls were recruited. The microvasculature and microcirculation of the temporal bulbar conjunctiva of the right eyes were assessed using a functional slit-lamp biomicroscope. Vascular variables included blood flow velocity (BFV), blood flow rate (BFR), microvascular network density and vessel diameter. A fractal analysis was performed using the box counting method to measure the fractal dimension (Dbox) representing the vessel density. The bulbar BFV was 0.59 +/- 0.09 mm/s in the DEL) group and 0.47 +/- 0.12 in the control group (P < 0.001). BFR was 169.5 +/- 1.8 in the DED group compared to the control group (107.2 +/- 49.6) (P < 0.001). Dbox was higher in DED patients (1.65 +/- 0.04) than controls (1.60 +/- 0.07, P < 0.05). Moreover, the vessel diameter was larger in the DED group (21.8 +/- 1.8 mu m) compared with controls (17.9 +/- 2.2 mu m, P < 0.001). Dbox was positively related with ocular surface disease index (OSDI) in patients with DED (r = 0.54, P = 0.008). Microvascular alterations were found in the bulbar conjunctiva of DED patients, including increased blood flow velocity, higher vessel density and larger vessel diameter.