Mechanical Properties of the Long-Head of the Biceps Tendon Are Altered in the Presence of Rotator Cuff Tears in a Rat Model
Mechanical Properties of the Long-Head of the Biceps Tendon Are Altered in the Presence of Rotator Cuff Tears in a Rat Model
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DOI：
10.1002/jor.20770
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发表时间：
2009-03-01
影响因子：
2.8
通讯作者：
Soslowsky, Louis J.
中科院分区：
文献类型：
--
作者：
Peltz, Cathryn D.;Perry, Stephanie M.;Soslowsky, Louis J.
肩袖撕裂是导致关节负荷变化和功能缺陷的致残性疾病。临床上，肱二头肌肌腱长头的损伤与肩袖撕裂有关，这种损伤被认为随着撕裂尺寸的增加而增加。尽管它的重要性，存在争议的最佳治疗二头肌。这种情况的动物模型将允许对照研究，以调查这个问题的病因和潜在的治疗策略。我们通过分离单个（冈上肌）和多个（冈上肌+冈下肌或冈上肌+肩胛下肌）肩袖肌腱在大鼠模型中创建肩袖撕裂，并在损伤后4周和8周沿二头肌肌腱长头长度沿着测量机械性能。肱二头肌的横截面积在存在单个肩袖肌腱撕裂的情况下增加（类似于150%），在存在多个肩袖肌腱撕裂的情况下增加更大（高达220%）。一个和两个肌腱撕裂的模量值分别下降了43%和56%。此外，除了冈上肌之外，累及冈下肌的多处肌腱撕裂状况对二头肌肌腱的影响大于累及肩胛下肌和冈上肌的肌腱。最后，肱二头肌肌腱的机械性能恶化，随着时间的推移，在多个肩袖肌腱撕裂。因此，大鼠模型与肩袖撕裂时肱二头肌肌腱病理学的临床结果相关性良好，可用于评估病因和治疗方式。(C)2008骨科研究学会。由威利期刊公司出版J Orthop Res 27：416-420，2009
Rotator cuff tears are disabling conditions that result in changes in joint loading and functional deficiencies. Clinically, damage to the long-head of the biceps tendon has been found in conjunction with rotator cuff tears, and this damage is thought to increase with increasing tear size. Despite its importance, controversy exists regarding the optimal treatment for the biceps. An animal model of this condition would allow for controlled studies to investigate the etiology of this problem and potential treatment strategies. We created rotator cuff tears in the rat model by detaching single (supraspinatus) and multiple (supraspinatus+infraspinatus or supraspinatus+subscapularis) rotator cuff tendons and measured the mechanical properties along the length of the long-head of the biceps tendon 4 and 8 weeks following injury. Cross-sectional area of the biceps was increased in the presence of a single rotator cuff tendon tear (by similar to 150%), with a greater increase in the presence of a multiple rotator cuff tendon tear (by up to 220%). Modulus values decreased as much as 43 and 56% with one and two tendon tears, respectively. Also, multiple tendon tear conditions involving the infraspinatus in addition to the supraspinatus affected the biceps tendon more than those involving the subscapularis and supraspinatus. Finally, biceps tendon mechanical properties worsened over time in multiple rotator cuff tendon tears. Therefore, the rat model correlates well with clinical findings of biceps tendon pathology in the presence of rotator cuff tears, and can be used to evaluate etiology and treatment modalities. (C) 2008 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 27:416-420, 2009