Compensatory Growth Is Accompanied by Changes in Insulin-Like Growth Factor 1 but Not Markers of Cellular Aging in a Long-Lived Seabird
Compensatory Growth Is Accompanied by Changes in Insulin-Like Growth Factor 1 but Not Markers of Cellular Aging in a Long-Lived Seabird
复制标题
DOI：
10.1086/724599
复制
发表时间：
2023-07-01
影响因子：
2.9
通讯作者：
Heidinger，Britt J.
中科院分区：
文献类型：
--
作者：
Sirman，Aubrey E.;Schmidt，Jacob E.;Heidinger，Britt J.
发育中的生物体往往根据环境条件对生长进行可塑性改变，这可能是适应性的，但预计会带来长期成本。然而，对这些增长调整的中介机制和任何相关成本的了解较少。在脊椎动物中，在这种情况下可能很重要的一种机制是高度保守的信号传导因子胰岛素样生长因子1（IGF-1），它通常与出生后的生长呈正相关，与寿命呈负相关。为了验证这一想法，我们暴露圈养富兰克林的海鸥（Leucophaeus pipixcan）的生理相关的营养压力，限制食物供应在出生后的发展和研究对生长的影响，IGF-1，和两个潜在的生物标志物的细胞和有机体老化（氧化应激和端粒）。在食物限制期间，实验鸡的体重增加更慢，IGF-1水平低于对照组。限食后，实验鸡进行补偿性生长，这是伴随着IGF-1水平的增加。然而，有趣的是，实验处理或IGF-1水平的变化对氧化应激或端粒没有显著影响。这些研究结果表明，IGF-1是响应于资源可用性的变化，但在这个相对长寿的物种的发展过程中，与细胞衰老的标志物增加无关。
Developing organisms often plastically modify growth in response to environmental circumstances, which may be adaptive but is expected to entail long-term costs. However, the mechanisms that mediate these growth adjustments and any associated costs are less well understood. In vertebrates, one mechanism that may be important in this context is the highly conserved signaling factor insulin-like growth factor 1 (IGF-1), which is frequently positively related to postnatal growth and negatively related to longevity. To test this idea, we exposed captive Franklin’s gulls (Leucophaeus pipixcan) to a physiologically relevant nutritional stressor by restricting food availability during postnatal development and examined the effects on growth, IGF-1, and two potential biomarkers of cellular and organismal aging (oxidative stress and telomeres). During food restriction, experimental chicks gained body mass more slowly and had lower IGF-1 levels than controls. Following food restriction, experimental chicks underwent compensatory growth, which was accompanied by an increase in IGF-1 levels. Interestingly, however, there were no significant effects of the experimental treatment or of variation in IGF-1 levels on oxidative stress or telomeres. These findings suggest that IGF-1 is responsive to changes in resource availability but is not associated with increased markers of cellular aging during development in this relatively long-lived species.