Nonuniformity of inner and outer systolic wall thickening in conscious dogs.
Nonuniformity of inner and outer systolic wall thickening in conscious dogs.
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清醒狗的内、外收缩壁增厚不均匀。
DOI：
10.1152/ajpheart.1985.249.2.h241
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
RossJr,J
中科院分区：
文献类型：
--
作者：
Gallagher,KP;Osakada,G;Matsuzaki,M;Miller,M;Kemper,WS;RossJr,J
在13只清醒的狗中，通过植入声测微计连续测量近相邻位置处通过心肌的总壁厚（WT）和大约一半距离的外部WT，分析了收缩期壁增厚的心室差异。通过从总WT中减去外部WT获得内部WT。外壁测量值平均跨越外壁的44 +/- 10%（+/- SD）;衍生的内壁测量值跨越其余的56 +/-10%。静止时，外壁对总收缩期壁增厚的贡献率（FC）为29 +/-9%，显着低于内壁的FC（71 +/-9%）。这些数据与左心室横截面的简化建模非常一致，左心室横截面为两个同心环，预测壁的内半部分和外半部分的FC分别约为67%和33%。在跑台运动期间，内外壁增厚的程度显著增加（分别为30%和29%），但内外壁的相对FC保持不变。数据表明，收缩期壁增厚是不均匀的，这种不均匀性保持不变，在增加变力性和变时性刺激与运动。
Transmural differences in systolic wall thickening were analyzed in 13 conscious dogs by implanting sonomicrometers to continuously measure total wall thickness (WT) and outer WT approximately half the distance through the myocardium at a closely adjacent location. Inner WT was derived by subtraction of outer WT from total WT. Outer wall measurements spanned, on average, the outer 44 +/- 10% (+/- SD) of the wall; derived inner wall measurements spanned the remaining 56 +/- 10%. At rest the fractional contribution (FC) of the outer wall to total systolic wall thickening was 29 +/- 9%, which was significantly less than the FC of the inner wall, 71 +/- 9%. These data are in good agreement with simplified modeling of a cross section of the left ventricle as two concentric rings that predicts that the FC of inner and outer halves of the wall should be approximately 67 and 33%, respectively. During treadmill exercise, the extent of both inner and outer thickening increased significantly (30 and 29%, respectively) but the relative FC of the inner and outer wall remained the same. The data indicate that systolic wall thickening is nonuniform and that this nonuniformity remains constant during the increased inotropic and chronotropic stimulation associated with exercise.