VACCINE EFFICACY AND CONTROL MEASURES IN PERTUSSIS
VACCINE EFFICACY AND CONTROL MEASURES IN PERTUSSIS
复制标题
DOI：
10.1136/adc.66.7.854
复制
发表时间：
1991-07-01
影响因子：
5.2
通讯作者：
PALMER, SR
中科院分区：
文献类型：
--
作者：
PALMER, SR
彭布罗克郡圣大卫地区小学生爆发的百日咳疫情为评估百日咳疫苗的功效提供了机会。 当使用通报病例时，估计有效率为 88%，但如果将所有咳嗽两周或以上的儿童纳入其中，则该估计值下降至 68%。 与其他具有类似症状的病例相比，通报病例接种疫苗的可能性明显较低。 因此，基于通报病例的疫苗功效估计可能存在偏差。 然而，即使较低的估计也表明百日咳免疫接种是非常可取的，并且应该加大努力提高覆盖率。
An outbreak of pertussis in primary school-children in the St David's area of Pembrokeshire provided the opportunity to estimate pertussis vaccine efficacy. The estimate of efficacy was 88% when notified cases were used, but this fell to 68% when all children with bouts of coughing for two or more weeks were included. Notified cases were significantly less likely to have been vaccinated than other cases with similar symptoms. Therefore vaccine efficacy estimates based upon notified cases are likely to be biased. However, even the lower estimates suggest that pertussis immunisation is highly desirable and efforts to improve coverage should be increased.