Relationship between renal hemodynamic and natriuretic effects of atrial natriuretic factor.
Relationship between renal hemodynamic and natriuretic effects of atrial natriuretic factor.
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肾血流动力学与心房利尿钠因子利钠作用的关系。
DOI：
10.1152/ajprenal.1986.250.3.f520
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Maack,T
中科院分区：
文献类型：
--
作者：
Sosa,RE;Volpe,M;Marion,DN;Atlas,SA;Laragh,JH;VaughanJr,ED;Maack,T
通过6只麻醉犬的早期钳夹实验，研究了心房钠素（ANF）引起的肾脏血流动力学改变对其利钠作用的影响程度。对照期结束后，左肾灌注压（LK）降至80-90 mmHg，静脉滴注合成ANF（木耳素A）（0.3微克X分钟-1 X公斤体重）。恢复后，速尿(F)以1 mg/kg体wt的剂量给药。在作为时间对照的右肾（RK）中，ANF使肾小球滤过率（GFR）增加16 +/- 4% (P < 0.05)，钠排泄量（UNa V）增加261 +/- 63% (P < 0.05)，而尿渗透压（Uosm）降低36 +/- 7%，但不改变游离水清除率。ANF还能增加利尿(V)和钾尿（UKV）。F在不改变GFR的情况下产生相同的定性结果。在固定的LK中，ANF不能增加GFR （22 +/- 4 vs. 26 +/- 4 ml/min）、UNaV （30 +/- 9 vs. 33 +/- 11 mueq/min）、V和UKV，也不能降低Uosm （841 +/- 97 vs. 840 +/- 114 mosmol/kg H2O）。F对LK和RK有相似的作用。数据表明，当其肾血流动力学作用受阻时，ANF的利钠作用就会消失。此外，结果表明，ANF拮抗肾血管收缩的狗。结果与anf诱导的钠尿在很大程度上是由于钠的过滤负荷增加而进入冲刷的内髓质的观点一致。
The degree by which atrial natriuretic factor (ANF)-induced renal hemodynamic changes account for its natriuretic effect was determined by early clamp experiments in six anesthetized dogs. After control periods, perfusion pressure of the left kidney (LK) was reduced to 80-90 mmHg, and synthetic ANF (auriculin A) was infused intravenously (0.3 micrograms X min-1 X kg body wt). After recovery, furosemide (F) was administered as a bolus injection (1 mg/kg body wt). In the right kidney (RK), which served as a time control, ANF increased (P less than 0.05) glomerular filtration rate (GFR) 16 +/- 4% and Na excretion (UNa V) 261 +/- 63%, whereas it decreased urine osmolality (Uosm) 36 +/- 7% without changing free water clearance. ANF also increased diuresis (V) and kaliuresis (UKV). F produced qualitatively the same results without changing GFR. In the clamped LK, ANF failed to increase GFR (22 +/- 4 vs. 26 +/- 4 ml/min), UNaV (30 +/- 9 vs. 33 +/- 11 mueq/min), V, and UKV or to decrease Uosm (841 +/- 97 vs. 840 +/- 114 mosmol/kg H2O). F had similar effects in LK as in RK. The data demonstrate that the natriuretic effect of ANF is abolished when its renal hemodynamic actions are impeded. In addition, the results demonstrate that ANF antagonizes renal vasoconstriction in the dog. The results are consistent with the view that the ANF-induced natriuresis is due in great part to an increase in the filtered load of Na into a washed-out inner medulla.