Adventitial myofibroblasts contribute to neointimal formation in injured porcine coronary arteries
Adventitial myofibroblasts contribute to neointimal formation in injured porcine coronary arteries
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DOI：
10.1161/01.cir.94.7.1655
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发表时间：
1996-10-01
期刊：
影响因子：
37.8
通讯作者：
Zalewski, A
中科院分区：
文献类型：
--
作者：
Shi, Y;OBrien, JE;Zalewski, A
背景冠状动脉深中膜损伤后，外膜发生重塑变化。因为这个过程是与外膜肌成纤维细胞，这类似于中膜平滑肌（SM）细胞的形成，我们已经研究了肌成纤维细胞参与的发展neointima.Methods和Results在猪模型，严重的腔内冠状动脉损伤导致成纤维细胞增殖和外膜重塑。显著的外膜反应与增加的新生内膜形成相关（P
Background The adventitia undergoes remodeling changes after a deep medial coronary injury. Because this process is associated with the formation of adventitial myofibroblasts, which resemble medial smooth muscle (SM) cells, we have examined myofibroblast involvement in the development of neointima.Methods and Results In a porcine model, severe endoluminal coronary injury resulted in fibroblast proliferation and adventitial remodeling. Significant adventitial responses were associated with increased neointimal formation (P