Serum lipid levels and the risk of biliary tract cancers and biliary stones: A population-based study in China
Serum lipid levels and the risk of biliary tract cancers and biliary stones: A population-based study in China
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DOI：
10.1002/ijc.23307
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发表时间：
2008-05-15
影响因子：
6.4
通讯作者：
Hsing, Ann W.
中科院分区：
文献类型：
--
作者：
Andreotti, Gabriella;Chen, Jinbo;Hsing, Ann W.
胆道癌，包括胆囊癌、肝外胆管癌和瓦特壶腹，是一种罕见但极具致命性的恶性肿瘤。胆结石是胆道癌的主要危险因素，与高脂血症有关。作为在上海进行的一项基于人群的病例对照研究的一部分，中国，我们研究了血脂水平与胆结石和癌症的关系。随机抽取460例胆道癌患者(其中胆囊癌264例，肝外胆管141例，壶腹55例)，胆道结石981例，健康体检者858例。参与者完成了面对面的采访，并提供了过夜的空腹血液样本。与对照组(90-124 mg/dl)相比，甘油三酯含量最高的五分之一的参与者患胆结石的风险(95%CI=1.1-1.9)是对照组的1.4倍(95%CI=1.1-1.9)，患胆囊癌的风险(95%CI=1.3-2.8)是对照组的1.9倍(95%CI=1.3-2.8)，患胆道癌的风险是对照组的4.8倍(95%CI=2.8-8.1)。高密度脂蛋白(高密度脂蛋白)最低五分之一(
Biliary tract cancers, encompassing the gallbladder, extrahepatic bile diicts and ampulla of Vater, are rare but highly fatal malignancies. Gallstones, the predominant risk factor for biliary cancers, are linked with hyperlipidemia. As part of a population-based case-control study conducted in Shanghai, China, we examined the associations of serum lipid levels with biliary stones and cancers. We included 460 biliary cancer cases (264 gallbladder, 141 extrahepatic bile duct, and 55 ampulla of Vater), 981 biliary stone cases and 858 healthy individuals randomly selected from the population. Participants completed an in-person interview and gave overnight fasting blood samples. Participants in the highest quintile of triglycerides (>= 160 mg/dl) had a 1.4-fold risk of biliary stones (95% CI = 1.1-1.9), a 1.9-fold risk of gallbladder cancer (95% CI = 1.3-2.8), and a 4.8-fold risk of bile duct cancer (95% CI = 2.8-8.1), compared to the reference group (third quintile: 90-124 mg/di). Participants in the lowest quintile of high-density lipoprotein (HDL) (